Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

BACKGROUND Raltegravir is an HIV-1 integrase inhibitor approved for use in adults, children and infants ≥4 weeks of age. As alternatives to the original film-coated tablet, a chewable ethylcellulose (EC) tablet and oral granules for suspension (GFS) have been developed for use in children. The purpose of this study was to evaluate these formulations in adults prior to use in paediatric studies....

Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

   The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil 200 as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physic...

Mesalamine is a gold standard anti-inflammatory drug used to treat inflammatory bowel illnesses. It's usually and keep Ulcerative Colitis in remission mild moderate cases. rapidly cleared from circulation after being consumed orally, with an elimination half-life of only one hour. Oral intake delayed or slow released matrix formulations can acquire therapeutic concentration the intestines. The ...

objective eudragits are widely used polymers in the production of oral sustained release dosage forms. the application of these polymers in the production of inert insoluble matrices has been investigated. however the effect of particle size, compaction force and presence of aerosil 200 as a glidant on the properties of eudragit rs and rl matrices prepared by direct compression of their physica...

The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 as ...

D. Niblett, S. C. Porter, I. Gabbott, G. Reynolds, T. Morgan, K. Karan, J. Greenamoyer, R. Hach University of Manchester, Ashland Specialty Ingredients, AstraZeneca Purpose Aqueous film coating still remains a complex process in which the process parameters selected can have a major impact on ultimate product quality. In this study, a wide range of processing parameters was performed in order t...

OBJECTIVE To assess the safety and efficacy of a preparation of mesalazine (5-aminosalicylic acid) coated with a pH dependent resin (Eudragit L) as compared with sulphasalazine in patients with active mild to moderate ulcerative colitis. DESIGN Eight week randomised double blind parallel group study. SETTING Forty six gastroenterology outpatient clinics in seven countries. PATIENTS Two hu...