Renealmia alpinia (Rottb.) MAAS, obtained by micropropagation (in vitro) and wild forms have previously been shown to inhibit some toxic activities of Bothrops asper snake venom if preincubated before injection. In this study, assays were performed in a murine model in which extracts were administered for three days before venom injection. R. alpinia extracts inhibited lethal activity of B. asp...

BACKGROUND/OBJECTIVES Sonchus asper is used extensively as an herbal anti-inflammatory for treatment of bronchitis, asthma, wounds, burns, and cough; however, further investigation is needed in order to understand the underlying mechanism. To determine its mechanism of action, we examined the effects of an ethyl acetate fraction (EAF) of S. asper on nitric oxide (NO) production and prostaglandi...

Mutations in the tumor suppressor gene TP53 are associated with a wide range of different cancers and may have prognostic and therapeutic implications. Methods for rapid and sensitive detection of mutations in this gene are therefore required. In order to make screening more effective, a commercially available TP53 genotyping microarray from Asper Biotech has been constructed by arrayed primer ...

The Greek ἦμαρ and the Armenian awr, both meaning 'day', are uniformly considered to be cognates without further correspondences within Indo-European. There is, however, no consensus with respect details of this etymological connection. connection between ἡμέρα has thus far not found a satisfying solution concerning origin rough breathing latter. Drawing elaborating on an etymology proposed for...

I compared diets of prickly sculpin, Cottus asper, and juvenile fall-run chinook salmon, Oncorhynchus tshawytscha, in the lower Mokelumne River, California, from January through June during 1998 and 1999. Prickly sculpin fed primarily on chironomid (Diptera) larvae and hydroptilid and hydropsychid (Trichoptera) larvae. Juvenile chinook salmon fed on zooplankton, plus chironomid, hydroptilid, an...

BACKGROUND Sonchus asper (SA) is traditionally used for the treatment of various ailments associated with liver, lungs and kidneys. This study was aimed to investigate the therapeutic potential of nonpolar (hexane, SAHE; ethyl acetate, SAEE and chloroform, SACE) and polar (methanol, SAME) crude extracts of the whole plant. METHODS To achieve these goals, several parameters including free-radi...

BACKGROUND Leber congenital amaurosis (LCA) is the most severe form of inherited retinal visual impairment in children. So far, mutations in more than 20 genes have been known to cause LCA and among them, RPE65 is a suitable candidate for gene therapy. The mutational screenings of RPE65 and other LCA genes are requisite in support of emerging gene specific therapy for LCA. Therefore, we have ca...