Neuroblastoma is a disease that observed in early childhood, originating from the sympathetic nervous system and very difficult to treat. Etoposide, topoisomerase 2 inhibitor, one of agents used cancer treatment. Galangin puerarin are plant-based antioxidants with anticancer properties. Since apoptosis induction methods treatment, evaluation mRNA expression levels apoptosis-related genes aimed ...

Mục tiêu: tiêu nghiên cứu nhằm mô tả đặc điểm lâm sàng, cận sàng và đánh giá tỷ lệ đáp ứng của phác đồ Cisplatin/etoposide trên bệnh nhân ung thư phổi thần kinh nội tiết tế bào lớn giai đoạn tái phát, di căn tại Bệnh Viện K từ tháng 1/2018 đến 10/2021. phương pháp cứu: cắt ngang hồi 33 được điều trị hóa chất Cisplatin/Etoposide Kết quả: Tuổi trung bình nhóm là 62 (35-69 tuổi). Tỉ nam/nữ 7,26/1....

PURPOSE Glioblastoma (GBM) inevitably recurs despite surgery, radiation, and chemotherapy. A subpopulation of tumor cells, GBM stem cells (GSC), has been implicated in this recurrence. The chemotherapeutic agent etoposide is generally reserved for treating recurrent tumors; however, its effectiveness is limited due to acute and cumulative toxicities to normal tissues. We investigate a novel com...

Human glioblastomas that express Fas/CD95 receptor are highly resistant to conventional brain tumour therapies. The aim of this study is to evaluate anti-tumour properties of a combination of Fas ligand (FasL) plus etoposide with or without dexamethasone on intracerebral experimental glioblastomas. The human Fas-expressing glioblastoma cell line, U-87 MG, was firstly studied in vitro for apopto...

To develop a nontoxic system for targeting therapy, a new highly ordered hierarchical mesoporous calcium carbonate nanospheres (CCNSs) as small drug carriers has been synthesized by a mild and facile binary solvent approach under the normal temperature and pressure. The hierarchical structure by multistage self-assembled strategy was confirmed by TEM and SEM, and a possible formation process wa...

Tumor microenvironment play role in angiogenesis and carcinogenesis. Etoposide, a known topoisomerase II inhibitor induces DNA damage resulting in cell cycle arrest. We developed a novel Etoposide analogue, Quinazolino-4β-amidopodophyllotoxin (C-10) that show better efficacy in regulating cell proliferation and angiogenesis. We evaluated its role on expression of microRNAs-15, 16, 17 and 221 an...

AIM In this paper effect of combinational usage of calprotectin and etoposide on AGS cell line is studied. BACKGROUND Application of combined toxic agents such as etoposide and cicplatin are commonly used for chemotherapy purposes. As a matter of fact, calprotectin and etoposide were both applied on human gastric adenocarcinoma cell line (AGS) as antitumor agents. Both calprotectin and etopos...

Previously, we reported that glucose-deprived astrocytes are more vulnerable to the cytotoxicity of peroxynitrite, the reaction product of nitric oxide and superoxide anion. The augmented vulnerability of glucose-deprived astrocytes to peroxynitrite cytotoxicity was dependent on their proliferation rate. Inhibition of cell cycle progression has been shown to inhibit the apoptotic cell death occ...