The solvent induced polymorphism observed in a cyclometalated iridium(iii) ethylenediamine ionic complex is a new tool to modulate and enhance emission in the solid crystalline state.

New chemotherapeutics are urgently needed to combat malaria. We previously reported on a novel series of antimalarial, ethylenediamine-based inhibitors of protein farnesyltransferase (PFT). In the current study, we designed and synthesized a series of second generation inhibitors, wherein the core ethylenediamine scaffold was varied in order to examine both the homology model of Plasmodium falc...

Intravenous aminophylline is used as a first line treatment for bronchial asthma. This preparation consists of theophylline or a salt of theophylline dissolved in a solution of ethylenediamine, which confers greater solubility and reduces the alkalinity of the drug.1 In clinical usage side effects of tachycardia, seizures and nausea are well known. We report on the much less common, but clinica...

A simple and precise HPLC method was developed for estimation of Montelukast sodium (MTKT) and Levocetirizine dihydrochloride (LCTZ) in pure and pharmaceutical dosage form. HPLC separation was achieved with a Phenomenex (Torrance, CA) C18 column (250 mm × 4.6 mm id, 5 μm particle size) as stationary phase and methanol: Trichloroacetic acid: Acetonitril (90:5:5, v/v/v) as eluent, at a flow rate ...

BACKGROUND A water based combination of 0.1% octenidine dihydrochloride and 2% 2 - phenoxyethanol is registered in many European countries as an antiseptic solution (octenisept®) for topical treatment with high antimicrobial activity for human use, but octenidine based products have not been registered for veterinary use yet. The aim of the present study was to investigate whether octenidine di...

OBJECTIVE Thrombin is implicated in the genesis of arrhythmias and activation of thrombin receptors exacerbated ventricular arrhythmias following coronary artery ligation. The present study was designed to investigate the possible protective effect of the protease-activated receptor-1 antagonist, SCH79797 against ischemia and reperfusion arrhythmias in the rat heart. MATERIALS AND METHODS Hea...

Three types of copper sulfides including CuS, Cu7S4 and Cu9S5 were successfully synthesized at different concentrations of ethylenediamine in a liquid phase synthesis process. The whole shape evolution of Cu7S4 microstructures could be manipulated by adjusting the concentration of ethylenediamine. This study indicates that the coordination chemistry of ethylenediamine ligands and copper cations...