The aim of the study was to consider the qualifications necessary for the procedure, the surgical treatment, and the long-term results. Material and methods. During the period between 1990 and 2005, twenty-five patients with benign esophageal tumors underwent treatment. Clinical symptoms, the size and localization of the tumor, and histological type were considered in cases of patients qualifie...

The aim of the study was to consider the qualifications necessary for the procedure, the surgical treatment, and the long-term results. Material and methods. During the period between 1990 and 2005, twenty-five patients with benign esophageal tumors underwent treatment. Clinical symptoms, the size and localization of the tumor, and histological type were considered in cases of patients qualifie...

BACKGROUND Tumor length is an important prognostic factor for many carcinomas, but its role in esophageal cancer remained undetermined. The aim of this study was to investigate the effect of tumor length on survival for patients with confined tumors (grade pT1-2) without lymph-node metastases in esophageal squamous cell carcinoma. METHODS We enrolled 201 patients with esophageal squamous cell...

M2 macrophages was domesticated by tumor microenvironment to produce some angiogenic molecules and protease, facilitating angiogenesis and matrix breakdown, promoting tumor invasive and metastasis. However, The function of M2 macrophages to progression of eophageal carcinoma, especially Kazakh esophageal carcinoma is still dimness. This study aims to investigate M2 macrophages correlated with m...

TGF-b and Notch signaling pathways play important roles in regulating self-renewal of stem cells and gastrointestinal carcinogenesis. Loss of TGF-b signaling components activates Notch signaling in esophageal adenocarcinoma, but the basis for this effect has been unclear. Here we report that loss of TGF-b adapter b2SP (SPNB2) activates Notch signaling and its target SOX9 in primary fibroblasts ...

Metalloproteinase-9 (MMP-9) is the proteolytic enzyme degrading type IV collagen, and plays important role in the invasiveness and metastatic potential of tumor cells. The aim of the current study was to compare the association between the intensity of MMP-9 expression in neoplastic cells and in the interstitial inflammatory infiltrate cells in esophageal cancer with clinicopathological feature...

Re-irradiation is challenging for esophageal cancer patients with local-regional recurrence after initial radiotherapy. The purpose of this study is to establish a recurrent esophageal tumor model and investigate radiosensitizing effects of sodium glycididazole (CMNa). Tumor models were established by pre-irradiation (0 Gy, 10 Gy or 20 Gy) to the right hind leg of the nude mice 24 hours before ...

background: the marginal length from main tumor in esophageal cancer is a considerable issue regarding surgical management and adjuvant treatment; so we decided to study the contractility effect on the proximal surgical margin after immersing it in10% buffered formalin as a fixative. methods: the proximal marginal length of  ten sequential patients with esophageal cancer who underwent transhiat...

The incidence of esophageal adenocarcinoma has increased dramatically over the past 20 years. The causes for this change in incidence and the genetic defects that underlie tumorigenesis are unknown. We performed loss of heterozygosity (LOH) studies in esophageal adenocarcinomas in an effort to map the location of tumor suppressor genes involved in the initiation or progression of this cancer. A...

BACKGROUND IL-19 is expressed in esophageal squamous cell carcinoma (SCC), but its biological effect on esophageal cancer remains unclear. We determined the correlation between IL-19 expression levels and clinicopathological variables and explored the effects of IL-19 on the esophageal SCC in vivo and in vitro. METHODOLOGY/PRINCIPAL FINDINGS We determined the expression levels of esophageal S...