In 2006, a severe foodborne EHEC outbreak occured in Norway. Seventeen cases were recorded and the HUS frequency was 60%. The causative strain, Esherichia coli O103:H25, is considered to be particularly virulent. Sequencing of the outbreak strain revealed resemblance to the 2011 German outbreak strain E. coli O104:H4, both in genome and Shiga toxin 2-encoding (Stx2) phage sequence. The nucleoti...

Lactic acid bacteria (LAB) are gram positive and non- spore forming bacteria that can produce some special substances for growth inhibition of pathogenic, non-pathogenic and food spoilage bacteria. The aim of this study was to determine the inhibitory effects of Lactobacillus acidophilus PTCC1643 (DSM 20079) and Lactobacillus plantarum PTCC 1058 (ATCC 8014) cultural supernatants against urinary...

Heterocyclic compounds containing a pyrimidine nucleus are of special interests due to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivati...

background: with increasing use of antibiotics, the number and type of microbial resistance to antibiotics have been raised and at result the need for synthesis of new antimicrobials or acquire new sources of antimicrobial is indisputable. in this study the antimicrobial effects of the flowering aerial parts of glaucium vitellinum and gaillonia aucheri were investigated. m aterials and methods:...

Physalis alkekengi L. has been used as anti-infective plant in Iranian traditional medicine. To investigate antifungal activity of the plant extract, wild plant was collected and identified and the aerial parts were air dried and powdered subsequently macerated in solvent. Extracts were concentrated by rotary evaporator at 60 C under reduced pressure. Aqueous, ethanol and methanol extracts were...

Adhesins mediate the introduction of bacteria to the host in the sometimes life-long relationship of uropathogenic Esherichia coli (UPEC) and the human urinary tract. As a class of extracellular proteins, adhesins enable bacteria to adhere to and, in some cases, invade host tissue; adhesins render UPEC virulent and permit host colonization. Adhesin receptor interactions at the host interface de...

Searching for homologous DNA molecules, pairing of the molecules and exchange of the strand with one of a counterpart duplex molecule are a central process for homologous recombination. RecA protein in Esherichia coli has been known to play a pivotal role in the processes. The recA gene was identified by A.J. Clark and his colleagues more than w x 30 years ago 1 and the first biochemical activi...

Heterocyclic compounds containing a pyrimidine nucleus are of special interests thanks to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine deriv...

Ribonuclease P (RNase P) is involved in the processing of the 5' leader sequence of precursor tRNA (pre-tRNA). We have found that RNase P RNA (PhopRNA) and five proteins (PhoPop5, PhoRpp21, PhoRpp29, PhoRpp30, and PhoRpp38) reconstitute RNase P activity with enzymatic properties similar to those of the authentic ribozyme from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. We report h...