In a meta-analysis of two identically designed, well-controlled, randomized, double-blind clinical trials, we compared 5 days of dirithromycin with 7 days of erythromycin for acute exacerbations of chronic bronchitis. Five hundred and thirty-one patients were randomized to receive dirithromycin (500 mg od) for 5 days and 526 patients were randomized to receive erythromycin (250 mg qid) for 7 da...

background and objectives: macrolide, lincosamide and streptogramin b (mlsb) antimicrobial agents are widely used in the treatment of staphylococcal infection. clindamycin is the medicine of choice for some staphylococcal infections, particularly skin and soft tissues infections. erythromycin and clindamycin are two distinct classes of antimicrobial agents which inhibit protein synthesis in bac...

background: streptococcus group b (gbs) or streptococcus agalactiae is typically associated with neonatal disease and infection in pregnant women. mortality of gbs sepsis in neonates is over 50% and is particularly high in preterm infants. gbs also causes invasive infection in pregnant and non-pregnant women including urinary tract infection (uti). penicillin-derived antibiotics remained as cho...

background acne vulgaris is a multifactorial disease of the pilosebaceous unit. malassezia furfur is one of the causative agents of the disease.it provides a proper environment for propionibacterium to grow. miconazole inhibits the propionibacterium growth by its fungicidal activity. objectives the aim of this study was to evaluate the treatment of acne vulgaris using the combination of topical...

BACKGROUND There is evidence from previous works that bacterial secondary metabolism may be stimulated by genetic manipulation of RNA polymerase (RNAP). In this study we have used rifampicin selection as a strategy to genetically improve the erythromycin producer Saccharopolyspora erythraea. RESULTS Spontaneous rifampicin-resistant (rif) mutants were isolated from the parental strain NRRL2338...

Different mechanisms of erythromycin resistance predominate in group C and G streptococcus (GCS and GGS, respectively) isolates collected from 1992 to 1995 in Finland. Of the 21 erythromycin-resistant GCS and 32 erythromycin-resistant GGS isolates, 95% had the mefA or mefE drug efflux gene and 94% had the ermTR methylase gene, respectively.

A mutant of Staphylococcus aureus was isolated in which lincomycin and carbomycin (but not erythromycin) induced resistance to erythromycin. This pattern displayed a reversal of the usual specificity of induction seen in the erythromycin-inducible parent strain from which the mutant was selected.

Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). Chronicle implant-induced osteomyelitis was established by MRSA infection in m...

BACKGROUND/AIM Macrolide and lincosamide antibiotics are used for the treatment of staphylococcal infections, especially for penicillin-allergic patients. In the present study, we evaluate the prevalence of resistance to macrolide and lincosamide antibiotics among staphylococci isolates. MATERIALS AND METHODS A total of 200 staphylococcal clinical isolates were collected from January 2012 to ...

The combination of beta-lactam antibiotics and macrolides is often recommended for the initial empirical treatment of acute pneumonia in order to obtain activity against the most important pathogens. Theoretically, this combination may be inexpedient, as the bacteriostatic agent may antagonize the effect of the bactericidal agent. In this study, the possible interaction between penicillin and e...