The exon 14 JAK2 V617F mutation has been well established as a driver mutation in polycythemia vera (PV) and other myeloproliferative neoplasms. JAK2 exon 12 mutations have also been implicated in PV, although patients with these mutations may show isolated erythrocytosis. Recently additional JAK2point mutations have been described-all in regions encoding the pseudokinase domain that regulates ...

E RYTHROCYTOSIS has been associated with various types of tumors.1 In some of these cases, the tumor was found to contain a substance which was similar to erythropoietin both immunochemically and in biologic activity. We shall here describe what we believe to be the first reported case of a patient with a leiomyoma of the esophagus and erythrocytosis. Experiments to determine the etiology of th...

Erythroid progenitor growth, the serum hormones that regulate erythropoiesis, and the effect of patient's serum on the growth of normal erythroid progenitors were assessed in eight patients with end-stage renal disease (ESRD) and erythrocytosis. All patients were male and had been on maintenance dialysis, they had a hematocrit >50% and/or a red blood cell count >6 x 10(12)/L and an arterial oxy...

CE Email comments/questions to [email protected], fax 800-556-3288, or log on to www.VetLearn.com Erythrocytosis in dogs and cats has various causes. Relative erythrocytosis is associated with a normal red blood cell (RBC) mass, whereas absolute erythrocytosis (primary and secondary) is characterized by increased numbers of RBCs. Primary erythrocytosis is a rare myeloproliferative diseas...

SUMMARY This case report focuses on a 71-year old patient affected by unknown dyspnea and erythrocytosis referred by his general practitioner to our center for specialist advice after a hematological examination had excluded polycythemia vera on grounds of negative test for JAK2 V617F/exon 12 mutation. An accurate clinical history and physical examination accompanied by respiratory function tes...