The studies reported here were conducted on a patient with congenital porphyria who excretes large amounts of uroporphyrin I and coproporphyrin I. They were directed to the following problems: (a) to determine whether glycine is specifically utilized in the biologic synthesis of porphyrins related to the etioporphyrin I configuration as it is utilized in the synthesis of protoporphyrin which is...

We compared two commonly used primary screening methods (FEP and ZnP) for detecting Pb poisoning in children, used according to three major protocols. The results showed that FEP and ZnP values were comparable for only 36% of the children examined; 54% had FEP greater than ZnP and 10% had ZnP greater than FEP. One would identify approximately twice as many children with Pb greater than 300 micr...

An NADPH-dependent reductase, first shown in the 1930s to catalyze the methylene blue-dependent reduction of methemoglobin in erythrocytes, has now been characterized as a high-affinity heme-binding protein and has been detected in liver. Highly purified bovine erythrocyte reductase binds protohemin to form a 1:1 complex with a Kd of 7 nM. Binding of protohemin completely inhibits reductase act...

background: anemia is common throughout the world, remarkably in developing countries. our aim is to calculate normal hemoglobin and other hematological indices in southwest of iran. materials and methods: a random selection of 500 healthy males and 500 healthy females was done in the age group of 13 to 65 years. a complete blood count (cbc) was performed in all participants. results: hemoglobi...

The recombinant antibodies RB217, RB218 and RB219 detect protoporphyrin IX by ELISA.

OBJECTIVE To evaluate the efficacy of IV iron supplementation of anemic, critically ill trauma patients. DESIGN Multicenter, randomized, single-blind, placebo-controlled trial. SETTING Four trauma ICUs. PATIENTS Anemic (hemoglobin < 12 g/dL) trauma patients enrolled within 72 hours of ICU admission and with an expected ICU length of stay of more than or equal to 5 days. INTERVENTIONS Ra...

OBJECTIVES To compare the effects of wheat flours fortified with NaFeEDTA, FeSO4 and elemental iron (electrolytic iron), in improving iron status in anemic students. METHODS Four hundreds anemic students (11 to 18 years old) were divided into four groups and given wheat flour fortified with different iron fortificants at different concentrations: control group (no added iron); NaFeEDTA group ...