Steroid hormones can have profound effects on prostate tumor development making it important to define steroid receptor expression in prostate tissues. For this purpose, androgen receptor (AR) and estrogen receptor (ERa and ERb) expression was quantified in 12 clinically localized and 11 hormone-refractory sporadic prostate tumors, using real-time quantitative reverse transcription-PCR assays. ...

Many of the effects of estrogens on the uterus are mediated by ERa, the predominant ER in the mature organ. Because of the poor reproductive capacity of ERb knockout (BERKO) female mice (small litter size, multiple-resorbed fetuses), the role of uterine ERb was explored. In the immature uterus, ERa and ERb are expressed at comparable levels in the epithelium and stroma, and 17b-estradiol (E2) t...

Benassayag, C., M. J. Leroy, V. Rigourd, B. Robert, J. C. Honoré, T. M. Mignot, M. C. Vacher-Lavenu, C. Chapron, and F. Ferré. Estrogen receptors (ERa/ERb) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1112–E1118, 1999.—The distributions of the mRNAs for estrogen receptors (ERa and ERb) and their binding propert...

General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edin...

This article presents ERB, the ESA Ravenscar Benchmark. ERB aims at providing a synthetic benchmark comparing the efficiency of various Ada Ravenscar implementations and the RTEMS C implementation featuring the native threading model. ERB is original compared to existing Ada benchmarks, such as the ACES or the PIWG, not only because it is the first Ada Ravenscar benchmark, but also because it p...

Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERBα and β, regulate sleep architecture and emotional behaviour...

The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expr...

This paper uses calibrated versions of a sticky-price currency-substitution model to compare the initial dynamics and welfare costs of three types of stabilization program: Ž . Ž . exchange-rate-based ERB , money-based MB , and money-based with initial reliqueficaŽ . tion MBR . ERB and MBR programs are found to induce an initial expansion in real activity, whereas MB programs are initially cont...