The study of the Mediterranean cyclones from a climatological point of view has been one of the objectives of the first phase of WMO WWRP MEDEX (MEDiterranean EXperiment) project. It has been revealing itself like a good procedure for extracting conclusions about their characteristics and behaviour. The implementation on ECMWF ERA40 reanalysis of the method for detecting and tracking the cyclon...

The age of stratospheric air is computed with a trajectory model, using ECMWF ERA-40 3-D-Var and operational 4-D-Var winds. The sensitivity to the forecast period and assimilation technique are studied, and the results are compared with observations and with results from a chemistry transport model that uses the same data sets. A large 5 number of backward trajectories is started in the stratos...

social changes and considering people’s needs are seen as the most important issues in the changes of persian poetry in constitutional era. the writers of this article have considered the views of western and iranian critics to study the function of the addressee in the changes of persian poetry in constitutional era. the use of such a study is that the writers have found and analyzed many soci...

Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-a (ERa). Phosphorylation of both ERa and AIB1 has been shown to have profound effects on their functions. In addition, proteasome-mediated degradation plays a major role by regulating their stability and activity. CK1d, a member of the ubiqui...

Breast cancers with estrogen receptor a (ERa) expression are often more differentiated histologically than ERa-negative tumors, but the reasons for this difference are poorly understood. One possible explanation is that transcriptional cofactors associated with ERa determine the expression of genes which promote a more differentiated phenotype. In this study, we identify one such cofactor as co...

The contents of ascorbic acid (AsA) and erythrobic acid (ErA) in the tissues of guinea pigs intraperitoneally injected with AsA and/or ErA were determined to learn the difference in their retention in the tissues. After 10 d of AsA depletion, the guinea pigs were intraperitoneally injected with 5 mg of AsA, or 5 mg of ErA, or 5 mg of each. At day 5 of repletion, the guinea pigs were killed and ...

badi’ iyaat – created as a new technique in a period of arabic literature, that is known as the decline era. the study of this technique as a form of poetry in this era, creates a cloud of doubt for naming the period. there have been many poets with thousands of great poems that reflect the prominence of this era not its decline. the writer of this article has studied badi’ iyaat in khazaanat –...

3-Methylcholanthrene (3MC) is an aryl hydrocarbon receptor (AhR) agonist, and it has been reported that 3MC induces estrogenic activity through AhR-estrogen receptor A (ERA) interactions. In this study, we used 3MC and 3,3V,4,4V,5pentachlorobiphenyl (PCB) as prototypical AhR ligands, and both compounds activated estrogen-responsive reporter genes/gene products (cathepsin D) in MCF-7 breast canc...

Oestrogen protects the heart from ischaemic injury. The current study aims to characterise two novel oestrogen receptor (ER) ligands, an ERa agonist ERA-45 and an ERb antagonist ERB-88, and then use them to investigate the roles of ERa and ERb in mediating the cardioprotection by E from ischaemia– reperfusion injury in the rat. The ER ligands were characterised by gene transactivation assay usi...

in terms of time, iranian mystic seyyed jaafar kashfi belongs to the era that is known as the end of the political thought era, from the perspective of decline theory. however, he is one of the great thinkers of the qajar era who in his two books entitled “tohfat al-muluk” and “mizan al-muluk” presented his political thought on the basis of mystical way. the main question in this research is wh...