We evaluated serial enzyme and bilirubin determinations as aids to diagnosis of Epstein-Barr virus-induced infectious mononucleosis (121 cases) and the heterophil-negative mononucleosis-like illness due to cytomegalovirus (33 cases). Laboratory evidence for either type of mononucleosis includes mild to moderate hepatic dysfunction, with aspartate aminotransferase activity increased, but lower t...

ulcerative colitis (uc) is one type of inflammatory bowel disease (ibd). herpes viruses have been suggested as possible etiological agents of uc and crohn’s disease (cd). the aim of this study was to investigate the prevalence of herpes simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with uc in comparison with healthy subjects by using pcr technique. in this ...

B-lymphoblastoid cell-lines may develop spontaneously in mononuclear cells from patients with multiple sclerosis, an observation rarely seen in healthy individuals. Examination of such spontaneously established B-cell lines reveal the presence of Epstein-Barr virus and retrovirus particles. We have speculated that in predisposed individuals, a dual infection with retrovirus and late acquired Ep...

The immune adherence hemagglutination assay was found to be as sensitive and specific as the indirect immunofluorescence technique for titration of antibodies to Epstein-Barr virus capsid antigen. Satisfactory virus capsid antigen-specific and negative control antigens for the immune adherence hemagglutination assay were prepared from cell extracts of the Epstein-Barr virus producer P3HR-1 and ...

Epstein-Barr virus was observed by electron microscopy in human lympho­ blastoid cells derived from a rhabdomyosarcoma. Replication of virus particles was stimulated approximately 1 0 fold after treatment of the cells with either 5'-iododeoxyuridine or 5'-bromodeoxyuridine. The evidence supports the con­ cept that the entire Epstein-Barr virus genome persists in some cells of this type. The dat...

CT: computed tomography EBER-ISH: Epstein-Barr viruseencoded RNA in situ hybridization EBV: Epstein-Barr virus LYG: lymphomatoid granulomatosis INTRODUCTION Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder that involves the skin in approximately 50% of cases. We describe a patient with LYG who first presented with cutaneous lesions. His skin biopsy failed to show ...

NPC-KT cl.S61, a subclone derived from an epithelial-nasopharyngeal carcinoma hybrid cell line (NPC-KT), showed cytopathic changes characteristic of herpesvirus replication, including formation of multinucleated giant cells and inclusion bodies, when Epstein-Barr virus replicative cycle was induced by 5-iodo-2'-deoxyuridine. Acyclovir (an inhibitor of herpesvirus DNA polymerase), Epstein-Barr v...

Attempts were made to superinfect epithelial explant cell cultures prepared from nasopharyngeal carcinomas with Epstein-Barr virus. Virus-specific markers were observed in such cultures 3 days after superinfection. In addition, expression of Epstein-Barr virus early antigens was observed in epithelial cell explant cultures treated with iododeoxyuridine. The results suggest that epithelial cells...

background and aims: ebv is a human herpesvirus that infects more than 90% of the world’s population. although, benign and asymptomatic for most cases, the infection can cause many nonmalignant and malignant disorders of lymphoid and epithelial origins. the objective of this study was detection of im prevalence in neyshabur, northeast iran from 2010-2014.   materials and methods: this cross-sec...

introduction: ebv is categorized as herpesviridans and by nature is a lymph crypto virus. studies have demonstrated that ebv will infect 80 to 90 percent of patients during the first year and there is a close relation between kidney malfunction and ebv infection. reactivation of the virus excites the immune system, and ultimately leads to rejection of kidney. the purpose of this study was to de...