Unverricht-Lundborg disease (EPM1), caused by mutations in the cystatin B gene (CSTB), is an autosomal recessively inherited disorder. It is the most common form of progressive myoclonus epilepsy. The prevalence of EPM1 is increased particularly in Finland where it is 4:100 000, offering a unique opportunity to study a large patient population. EPM1 is characterized by stimulus-sensitive and ac...

Electromechanical wave imaging (EWI) has been show capable of directly and entirely non-invasively mapping the trans mural electromechanical activation in all four cardiac chambers in vivo. In this study, we assessed EWI repeatability and reproducibility, as well as its capability of localizing electronic and, for the first time, biological pacing locations in closed-chest, conscious canines. E...

Background: Selective dorsal rhizotomy (SDR) is an established strategy for treating spastic cerebral palsy. The applied techniques and criteria of intraoperative electrophysiological monitoring (EPM) for selected transected rootlets vary between different centers; therefore its validity has been questioned. Objective: The aim of this study is to evaluate the applied techniques of EPM used duri...

Models of anxiety and fear of novelty were evaluated using correlations and principal component analysis. A total of 84 pigs (LandracexYorkshire) from nine different litters were subjected to a tonic immobility (TI) test at the age of 2.5 weeks, an elevated plus-maze (EPM) at the age of 6 weeks, a light/dark (L/D) exploration test at the age of 7 weeks and an open-field (OF) test at the age of ...

We introduce and analyze an exterior-pointmethod (EPM) for constrained optimization problems with both inequality constraints and equations. We show that under the standard second-order optimality conditions the EPM converges to the primal–dual solution with 1.5-Q-superlinear rate.

We introduce and analyze an exterior-point method (epm) for constrained optimization problems with both inequality constraints and equations. We show that under the standard second-order optimality conditions the epm converges to the primal-dual solution with 1.5-Q-superlinear rate.

Background: Medicinal plants with natural antioxidants have been shown to be beneficial in a variety of complications such as anxiety. The elevated plus-maze (EPM) is one of the most widely used models to assess anxiety in small rodents. Objectives: This study was designed to characterize the anxiolytic-like activity of Borago officinalis (Linnaeus, family Boraginaceae) or Borage flowers extrac...

The elevated plus-maze (EPM) is currently used to study the neural basis of anxiety as well as to assess the anxietymodulating activity of various pharmacological agents. Although the anxiogenic stimulus is supposed to be the open space in this test, the anxiety-related behavioral baseline of rats is sensitive to numerous methodological-linked parameters [1]. In order to improve the quality of ...

The antiproliferative activity of the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl[μ-(2-ethylphenyl)methanol]dicobalt (Co-EPM) was investigated on malignant pleural mesothelioma (MPM) cell lines, having an epithelioid or a sarcomatoid phenotype. In sarcomatoid cell lines Co-ASS was more potent than Co-EPM and the prototypal metal...

Rat bone marrow (BM) small cells were enriched by velocity sedimentation, further separated by means of free-flow electrophoresis, and characterized using Tand B-cell-specific surface markers. More than 80% of these cells were small lymphocytes by morphological criteria and reacted with lymphocyte-specific antisera. A minority of cells had high electrophoretic mobility (EPM), carried surface an...