This writing (1) draws attention to the intricacies inherent to the pursuit of a universal seizure definition even when powerful, well-understood signal analysis methods are used to this end; (2) identifies this aim as a multi-objective optimization problem and discusses the advantages and disadvantages of adopting or rejecting a unitary seizure definition; and (3) introduces a probabilistic me...

After the change of editorship in March 2004, new goals were defined and it is custom to evaluate the results after a year of publishing. Seizure aims to develop as an international journal with a scope of Europe and beyond, with a clinical orientation, fast publication speed and increasing impact. In 2005 the impact factor is increased to an ''all-time high 1.5'', publication speed increased (...

NeuroCog FX, a computerized neuropsychological screening for serial examinations of patients with epilepsy and other neurological diseases, was developed to fill the gap between unspecific ratings and comprehensive assessments. Eight subtests address attention, working memory, verbal and figural memory, and language. The test duration is less than 30 minutes. In research contexts, the test can ...

1 Lyon Neuroscience Research Centre, INSERM U1028, CNRS UMR5292, Brain Dynamics and Cognition Team, Lyon, F-69000, France 2 Université Lyon 1, Lyon, F-69000, France 3 Hospices Civils de Lyon, Neurological Hospital, Functional Neurology and Epileptology Dept, Lyon, F-69003, France 4 CERMEP Imagerie du vivant, Bron, F-69003, France 5 INSERM, U1028, Lyon Neuroscience Research Centre, Recherche tra...

IntroductIon Psychiatry, in terms of neuropsychiatry, has experienced an impressive revival in the field of neurology over the past two decades. This especially holds true for epileptology (Reynolds and Trimble, 2009). A large number of studies have addressed depressive and other affective disorders in patients with seizures. Depression is now widely acknowledged as a frequent psychiatric comor...

Neuroactive steroids represent potential antiepileptic drugs. We tested a newly synthesized analogue of allopregnanolone 3alpha-hydroxy-21xi,22-oxido-21-homo-5alpha-pregnan-20-on (HOHP) against two types of pentylenetetrazol-induced seizures (100 mg/kg s.c.) in 12- and 25-day-old rats. Ganaxolone, a neuroactive steroid in clinical trials, served as a reference drug. Pretreatment with either ste...

The kindling phenomenon is classically investigated in epileptology research. The present study aims to provide further information about hippocampal kindling through computational processing data. Adult Wistar rats were implanted with dorsal hippocampal and frontal neocortical electrodes to perform the experiment. The processing data was obtained using the Spike2 and Matlab softwares. An inver...

Why seizures spontaneously terminate remains an unanswered fundamental question of epileptology. Here we present evidence that seizures self-terminate via a discontinuous critical transition or bifurcation. We show that human brain electrical activity at various spatial scales exhibits common dynamical signatures of an impending critical transition--slowing, increased correlation, and flickerin...