The effects of a brief hypoxic episode on synaptic activity in the CA1 region of the hippocampus were studied using the in vitro slice prepared from dietary Mg-deficient mouse. After 5 min of hypoxia, the synaptically evoked population spike was increased in amplitude and developed to an epileptiform discharge. The induction of the epileptiform discharge following hypoxia was prevented in the p...

The iron-induced model of post-traumatic chronic focal epilepsy in rats was studied by depth-electrode mapping to investigate the spread of epileptiform activity into subcortical brain structures after its onset in the cortical epileptic focus. Electrical seizure activity was recorded in the hippocampal CA1 and CA3 areas, amygdala and caudate-putamen, in rats with iron-induced chronic cortical ...

Polymicrogyria, a developmental cortical malformation associated with epilepsy, can be modeled in rats with a transcortical freeze lesion on the day of birth (P0) or P1. We have used field potential recordings to characterize the incidence, propagation patterns, and distribution of epileptiform activity in slices from rats with experimental microgyri. Interictal-like epileptiform activity was e...

The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. The new connections among granule cells provide a novel mechanism of synchronization that could enhance the participation of these cells in seizures. Despite the presence of robust recurrent mossy fiber growth, orthodromic or antidromic activation of granule cells usually doe...

Nine girls with Rett syndrome had 22 electroencephalographic studies performed over 5 years. Nineteen walking tracings demonstrated moderate background slowing. Focal epileptiform activity was observed in 13 studies, 10 of which had bilateral independent foci. Spikes were invariably maximal in central regions, diphasic or triphasic, and of very short duration. In 3 patients, epileptiform activi...

Purpose: Our study aimed to investigate the effects of dexmedetomidine on basal synaptic transmission in the rat hippocampus. We also examined dexmedetomidine in an animal epilepsy model, with further investigation into the role of specific antagonists on the alpha-2 adrenoceptors and the imidazoline receptors. Methods: All of the experiments used the CA1 region of hippocampal brain slices prep...

Introduction: Epilepsy is a neurological disorder that affects 1-2% of the world population and about 30% of patients are resistant to antiepileptic drug therapy. Therefore, new treatment alternatives are needed. In the present study, the possible neuroprotective effect of minocycline against epileptiform activity induced by pentylenetetrazole (PTZ) was assessed. Methods: Conventional intra...