background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

In this paper numerous alternative treatments in addition to pharmacological therapy are proposed for their use in epileptic patients. Epileptic animal models can play a crucial role in the performance evaluation of new therapeutic techniques. The objective of this research is to first develop various epileptic rat models; second, develop a portable wireless closed-loop seizure controller inclu...

In presurgical monitoring, focal seizure onset is visually assessed from intracranial electroencephalogram (EEG), typically based on the selection of channels that show strongest changes in amplitude and frequency. As epileptic dynamics increasingly considered to reflect potentially distributed neural networks, it becomes important also assess interrelationships between channels. We propose a w...

Introduction Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epileptic syndrome, mostly initiated before adolescence. It is usually preceded by myoclonic jerks (sudden brief involuntary muscle spasm) in the second decade of life. JME may be presented with different types of seizure activity. Simple bilateral myoclonic seizure is the most seen clinical presentation of...

When dogs or cats get seizures, epileptic seizures and epilepsy are usually thought of. However, it is important to take into account the existence of that similar but do not belong (non-epileptic seizures). Nonepileptic occur suddenly, short-term, disappear as quickly they occur, recur have no etiology can be non-neurological neurological origin. Unlike non-epileptic a specific neural origin r...

background: epilepsy is a severe disorder of the central nervous system that predisposes  the person to recurrent seizures. fifty million people worldwide suffer from  epilepsy; after alzheimer's and stroke, it is the third widespread nervous disorder. objective: in this paper, an algorithm to detect the onset of epileptic seizures  based on the analysis of brain electrical signals (eeg) has be...

Non-epileptic seizures (NES) is a descriptive term for a diverse group of disorders that refer to paroxysmal events that can be mistaken for epilepsy, but are not due to an epileptic disorder. “Non-epileptic seizure” is the preferred term. As confirmed by Steven Schachter, MD in his 1966 survey of American epileptologists, the majority of respondents considers this to be the preferred term as o...

Epileptic seizure detection is commonly implemented by expert clinicians with visual observation of electroencephalography (EEG) signals, which tends to be time consuming and sensitive to bias. The epileptic detection in most previous research suffers from low power and unsuitability for processing large datasets. Therefore, a computerized epileptic seizure detection method is highly required t...

PURPOSE To elucidate the mechanisms that regulate p-glycoprotein (PGP) expression and function in pharmacoresistant epilepsy, we investigated the effect of an ETB receptor antagonist (BQ788) and a p38 mitogen-activated protein kinase (p38MAPK) inhibitor (SB202190) on intractable seizures in chronic epileptic rats. METHODS Lithium-pilocarpine-induced chronic epileptic rats were used in the pre...

The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. However, poor surgical outcome suggests a complex relationship between foci and the surrounding network that drives seizure dynamics. We developed a novel technique to objectively track se...