نتایج جستجو برای: epha2

تعداد نتایج: 800  

2016
Jun Hasegawa Mayumi Sue Michiko Yamato Junya Ichikawa Saori Ishida Tomoko Shibutani Michiko Kitamura Teiji Wada Toshinori Agatsuma

Overexpression of EPHA2 has been observed in multiple cancers and reported to be associated with poor prognosis. Here, we produced an afucosylated humanized anti-EPHA2 monoclonal antibody (mAb), DS-8895a for cancer treatment. The antibody recognizes the extracellular juxtamembrane region of EPHA2 and therefore can bind to both full-length and truncated forms of EPHA2, which are anchored to cell...

Journal: :International journal of clinical and experimental pathology 2015
Hesheng Li Qinglei Sun Bing Han Xingquan Yu Baoguang Hu Sanyuan Hu

Deregulated microRNAs (miRNAs) have been shown to play important roles in cancer progression as a result of changes in expression of their target genes. In this study, we investigated the expression of miR-16b in eight hepatocellular carcinoma (HCC) cell lines, revealed the roles of miR-26b on hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion, and confirmed that EphA2 i...

2015
Prema Subbarayal Karthika Karunakaran Ann-Cathrin Winkler Marion Rother Erik Gonzalez Thomas F. Meyer Thomas Rudel

The obligate intracellular bacterium Chlamydia trachomatis invades into host cells to replicate inside a membrane-bound vacuole called inclusion. Multiple different host proteins are recruited to the inclusion and are functionally modulated to support chlamydial development. Invaded and replicating Chlamydia induces a long-lasting activation of the PI3 kinase signaling pathway that is required ...

2013
Nami Sugiyama Erika Gucciardo Olga Tatti Markku Varjosalo Marko Hyytiäinen Matthias Gstaiger Kaisa Lehti

Changes in EphA2 signaling can affect cancer cell-cell communication and motility through effects on actomyosin contractility. However, the underlying cell-surface interactions and molecular mechanisms of how EphA2 mediates these effects have remained unclear. We demonstrate here that EphA2 and membrane-anchored membrane type-1 matrix metalloproteinase (MT1-MMP) were selectively up-regulated an...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Shaji Abraham Deborah W Knapp Liang Cheng Paul W Snyder Suresh K Mittal Dinesh S Bangari Michael Kinch Lan Wu Jay Dhariwal Sulma I Mohammed

PURPOSE The EphA2 receptor tyrosine kinase is believed to play a role in tumor growth and metastasis. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers. The purpose of this work was to determine the expression of EphA2 and its ligand, Ephrin A-1, and E-cadherin in carcinoma of the urinary bladder, and determin...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Christopher J Herrem Tomohide Tatsumi Kathleen S Olson Keisuke Shirai James H Finke Ronald M Bukowski Ming Zhou Amy L Richmond Ithaar Derweesh Michael S Kinch Walter J Storkus

Whereas normally expressed at sites of cell-to-cell contact in adult epithelial tissues, recent studies have shown that the receptor tyrosine kinase EphA2 is overexpressed in numerous epithelial-type carcinomas, with the greatest level of EphA2 expression observed in metastatic lesions. In the current study, we have assessed EphA2 expression in archived renal cell carcinoma (RCC) tissues as it ...

2009
Gyungah Jun Hong Guo Barbara E. K. Klein Ronald Klein Jie Jin Wang Paul Mitchell Hui Miao Kristine E. Lee Tripti Joshi Matthias Buck Preeti Chugha David Bardenstein Alison P. Klein Joan E. Bailey-Wilson Xiaohua Gong Tim D. Spector Toby Andrew Christopher J. Hammond Robert C. Elston Sudha K. Iyengar Bingcheng Wang

Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract. Retroillumination re...

Journal: :Cancer prevention research 2009
Jennifer M Brannan Banibrata Sen Babita Saigal Ludmila Prudkin Carmen Behrens Luisa Solis Wenli Dong B Nebiyou Bekele Ignacio Wistuba Faye M Johnson

Overexpression of the receptor tyrosine kinase EphA2 occurs in non-small cell lung cancer (NSCLC) and a number of other human cancers. This overexpression correlates with a poor prognosis, smoking, and the presence of Kirsten rat sarcoma (K-Ras) mutations in NSCLC. In other cancers, EphA2 has been implicated in migration and metastasis. To determine if EphA2 can promote NSCLC progression, we ex...

2015
YUNYUN WANG YONG LIU GUO LI ZHONGWU SU SHULING REN PINGQING TAN XIN ZHANG YUANZHENG QIU YONGQUAN TIAN

Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the survival of NPC 5‑8F cells, compared with control cells exposed to the same concentr...

2014
JINSHENG XU JUNXIA ZHANG LIWEN CUI HUIRAN ZHANG SHENGLEI ZHANG YALING BAI

The receptor tyrosine kinase, ephrin type-A receptor 2 (EphA2), is normally expressed at sites of cell-to-cell contact in adult epithelial tissues, however, recent studies have shown that it is also overexpressed in various types of epithelial carcinomas, with the greatest level of EphA2 expression observed in metastatic lesions. In the present study, the association between the expression of E...

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