Head and neck squamous cell cancer (HNSCC) is the sixth leading cause of cancer-related deaths worldwide. These tumors are commonly diagnosed at advanced stages and mortality rates remain high. Even cured patients suffer the consequences of aggressive treatment that includes surgery, chemotherapy, and radiotherapy. In the past, in clinical trials, HNSCC was considered as a single disease entity...

BACKGROUND Adjuvant radiotherapy (RT) of regional lymph nodes (LN) in early breast cancer is still a matter of debate. RT increases the Overall survival (OS) rate of breast cancer patients after breast conserving surgery and after mastectomy in patients with involved LN. The contribution of RT to regional LN to this improvement was poorly identified. Recently, the results of three large randomi...

One of the most burning problems of modern urology still remains the treatment of bladder cancer, which has the highest recurrence rate of any malignancy. Depending on a patient's individual characteristics, the probability of recurrence of non–muscle invasive bladder cancer (NMIBC) at one–year ranges from about 20% to 72% and the probability of progression at five years ranges from about 5% to...

Fatigue is a major complaint among advanced cancer patients. Several instruments are available for measuring fatigue. The EORTC QLQ-C30 is one of the most frequently used health-related quality of life (HRQOL) instruments, and it includes a three-item fatigue subscale. Limited knowledge exists about the validity, performance and sensitivity of EORTC QLQ-C30 fatigue scale as compared with a fati...

BACKGROUND Health-related quality of life is often collected in clinical studies, and forms a cornerstone of economic evaluation. This study had two objectives, firstly to report and compare pre- and post-progression health state utilities in advanced melanoma when valued by different methods and secondly to explore the validity of progression-based health state utility modelling compared to mo...

IntroductionOlder patients with early breast cancer (EBC) derive modest survival benefit from chemotherapy but have increased toxicity risk. Data on the impact of for EBC quality life in older are limited, this is a key determinant treatment acceptance. We aimed to investigate its effect enrolled Bridging Age Gap study.Materials and methodsA prospective, multicentre, observational study ?70 yea...

Primary cutaneous lymphoma (CL), the second most frequent type of extranodal non-Hodgkin’s lymphoma (NHL), accounts for approximately one third of all cases of NHL. This is a very simple reason for having an issue of Haematologica specifically focused on this topic. Although most of the literature and clinical experience about CL come from dermatology, the history of the last 20 years clearly s...

geneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Mycopathologia. 2005;159:181-188. 6. Ellis M, Spence D, de Pauw B, et al. An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis. Clin Infect Dis. 19...

geneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Mycopathologia. 2005;159:181-188. 6. Ellis M, Spence D, de Pauw B, et al. An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis. Clin Infect Dis. 19...