BACKGROUND Stakeholders across the clinical trial enterprise have expressed concern that the current clinical trial enterprise is unsustainable. The cost and complexity of trials have continued to increase, threatening our ability to generate reliable evidence essential for making appropriate decisions concerning the benefits and harms associated with clinical interventions. Overcoming this ine...

The chapter presents the framework for agent-enabled dynamic composition of Semantic Web Services. The approach and the framework have been developed in several research and development projects by ISRG and IOG. The core of the methodology is the new understanding of a Semantic Web Service as a capability of an intelligent software agent supplied with the proper ontological description. It is d...

Optical Burst Switching (OBS) is a promising paradigm for the next-generation Internet infrastructure. In OBS, a key problem is to schedule bursts on wavelength channels with both fast and bandwidth efficient algorithms so as to reduce burst loss. To date, most scheduling algorithms avoid burst contention locally (or reactively). In this paper, we propose several novel algorithms for scheduling...

Therapy combining dinutuximab with granulocyte macrophage colony stimulating factor, interleukin 2, and isotretinoin has significant side effects; however, these complications are generally predictable and can be managed proactively.

BACKGROUND Complex problems do not respect academic disciplinary boundaries. Environmental health research is complex and often moves beyond these boundaries, integrating diverse knowledge resources to solve such challenges. Here we describe an evolving paradigm for interweaving approaches that integrates widely diverse resources outside of traditional academic environments in full partnerships...