In conditions of natural resource constraints and technogenic destruction the environment, there is a need to improve mechanisms for managing potential in regions while maintaining balance between consumption resources preservation quality environment. The article examines differentiation three Russian Federation - Ural, Siberian Far Eastern federal districts according state nature management f...

While the master regulator gene Sry on the mammalian Y chromosome controls the switch for initiating male sex differentiation, many other species rely on environmental factors for gonadal sex differentiation. Yet other species, like zebrafish, appears to rely on a multitude of genetic cues for gonadal sex differentiation. Zebrafish gonadal differentiation initiates with the onset of a juvenile ...

Phenotypic differentiation in size and fecundity between native and invasive populations of a species has been suggested as a causal driver of invasion in plants. Local adaptation to novel environmental conditions through a micro-evolutionary response to natural selection may lead to phenotypic differentiation and fitness advantages in the invaded range. Local adaptation may occur along a stres...

Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and div...

Phenotypic and genetic clines have long been synonymous with adaptive evolution. However, other processes (for example, migration, range expansion, invasion) may generate clines in traits or loci across geographical and environmental gradients. It is therefore important to distinguish between clines that represent adaptive evolution and those that result from selectively neutral demographic or ...

Genome-wide gene expression is re-programmed in response to external or internal factors such as environmental stress or genetic mutation, respectively, or as a function of endogenous processes such as cell proliferation or differentiation. Here we integrate expression profiling data that have been collected by our laboratory since 2001 and that interrogate more than 900 different experimental ...

Many amphibian species have wide altitudinal and latitudinal distribution ranges, and hence, different populations of the same species may face very different environmental constraints and selection pressures. Although the potential differences in selective regimes along altitudinal and latitudinal gradients are still largely unknown, a number of studies have documented conspicuous phenotypic d...

The induction of allergen-specific T helper 2 (Th2) cells by lung dendritic cells (DCs) is a critical step in allergic asthma development. Airway delivery of purified allergens or microbial products can promote Th2 priming by lung DCs, but how environmentally relevant quantities and combinations of these factors affect lung DC function is unclear. Here, we investigated the ability of house dust...