BACKGROUND Adult onset autoimmune enteropathy (AIE) is a rare condition characterized by diarrhea refractory to dietary therapy diagnosed in patients with evidence of autoimmune conditions. Auto-antibodies to gut epithelial cells and other tissues are commonly demonstrated. Despite increasing awareness, the pathogenesis, histologic, immunologic and clinical features of AIE remain uncertain. The...

Coeliac disease is a gluten-sensitive enteropathy that develops in genetically susceptible individuals. The disease exhibits many features of an autoimmune disorder. These include the production of highly specific anti-endomysial autoantibodies directed against the enzyme tissue transglutaminase. It is well accepted that wheat-, barley- and rye-based foods should be excluded in the gluten-free ...

the diabetes is an autoimmune disease, in which the role of autoantibodies is of a specific importance. the appearance of these autoantibodies can be the first symptom in the serum of type i diabetic patients, which may appear ten years before onset of the disease. the most important autoantibodies include glutamic acid decarboxylase autoantibodies (gad65-ab). this can be used as a good tool fo...

autoimmune hepatitis is a chronic hepatitis that occurs in children and adults of all ages. diagnosis is based upon characteristic serologic and histologic findings and the exclusion of other forms of chronic liver disease. guidelines issued by the aasld suggest the following diagnostic considerations: the diagnosis should be made in patients with compatible clinical signs, symptoms, and labora...

OBJECTIVE To test the hypothesis that the proximal small intestines of children with persistent diarrhea present morphometric and stereologic changes proportional to their nutritional status, using microscope images stored in a computer. METHODS Cross-sectional study with 65 pediatric patients, whose ages ranged from 4 months to 5 years, with persistent diarrhea for over 14 days. The nutritio...

objective: to investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among iranian patients before and after sodium valproate treatment.   patients and methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. serum antinuclear antibodies (ana), anti-cardiolipin antibodies (acl), a...

Mol. Nutr. Food Res. 2021, 65, 202100200 DOI: 10.1002/mnfr.202100200 An integral physicochemical and functional approach demonstrated that pepsin gliadin digest forms spontaneously amyloid-type nanostructures whose interaction with the Caco-2 enterocyte cellular model induces expression of selected mRNAs involved in activation immune cells. Therefore pathogenic role may be relevant for biodemic...