Case 1. Delivery (December 1962) was at the 7th month by caesarean section for fetal distress. At the time of the section an ovarian cyst was noted, and this was excised (see below). The baby (2400 g., 48 cm.) was covered with meconium. The skin of the trunk showed many purpuric spots. The abdomen was enlarged, with marked hepatosplenomegaly. Respiratory distress was severe, death occurring at ...

• The nature of the cellular changes that occur in an enlarging heart are unclear. Whether cardiac enlargement, even in the young, occurs by increase in size of the cell (hypertrophy) or cell division (hyperplasia) or both remains an unsettled question. Mitotic figures, an indication of hyperplasia, have not been convincingly demonstrated by microscopic study of the adult heart even when enlarg...

OBJECTIVES We sought to determine whether patients with congestive heart failure (CHF) avoid the left lateral decubitus (LLD) position during sleep and, if so, whether this avoidance would be more pronounced in those with greater degrees of cardiomegaly. BACKGROUND Anecdotal reports suggest that, in patients with CHF, the LLD position is associated with discomfort due to the enlarged apical h...

A 35 years old male presented with a two months history of progressively increasing dyspnoea. On examination he was in respiratory distress, afebrile, had prominent neck veins and an increased area of cardiac dullness. The heart sounds were muffled, and the abdomen was unremarkable except for an enlarged, tender liver. The blood count was normal, but the ESR was raised (60mm). X-ray chest showe...

G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventricles from male mutant mice were enlarged. There were no malformations in the va...

Rupture of a sinus of Valsalva aneurysm into the right ventricle produces a dramatic clinical syndrome characterized by a rapid and relentlessly unfavorable course. Early diagnosis is essential for surgical repair before an irreversible stage is reached. Cardiac catheterization and retrograde aortography confirmed the diagnosis in the case reported. With the aid of temporary circulatory occlusi...

Pulmonary arteriovenous malformations are rare vascular anomalies of the lung, only a few cases of which have been diagnosed prenatally. The diagnostic clue for prenatal diagnosis was cardiomegaly with a particularly enlarged left atrium. All previous cases of pulmonary arteriovenous malformations diagnosed prenatally have been reported as an isolated anomaly or in association with simple heart...