The goal of the present study was to evaluate the role of endoglin, a transforming growth factor-beta1 (TGF-beta1) accessory receptor, in the pathogenesis of renal fibrosis. This was achieved by testing a model of tubulo-interstitial fibrosis induced by unilateral ureteral obstruction in endoglin heterozygous (Eng(+/-)) mice. Northern and Western blot analysis revealed that endoglin expression ...

BACKGROUND AND PURPOSE Bone marrow-derived cells (BMDCs) home to vascular endothelial growth factor (VEGF)-induced brain angiogenic foci, and VEGF induces cerebrovascular dysplasia in adult endoglin heterozygous (Eng(+/-)) mice. We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation. METHODS BM transplantation was performed using adult wi...

OBJECTIVE Hereditary hemorrhagic telangiectasia is a genetic disorder characterized by visceral and mucocutaneous arteriovenous malformations (AVMs). Clinically indistinguishable hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 are caused by mutations in ENG and ALK1, respectively. In this study, we have compared the development of visceral and mucocutaneous A...

Increased levels of soluble endoglin (Sol-Eng) correlate with poor outcome in human cancer. We have previously shown that shedding of membrane endoglin, and concomitant release of Sol-Eng is a late event in chemical mouse skin carcinogenesis associated with the development of undifferentiated spindle cell carcinomas (SpCCs). In this report, we show that mouse skin SpCCs exhibit a high expressio...

This paper compares state-equation models to state-machine models. It compares continuous system models to discrete system models. The examples were designed to be at the same level of abstraction. This paper models these systems with the following methods: the state-space approach of Linear Systems Theory, set-theoretic notation, block diagrams, use cases, UML diagrams and SysML diagrams. This...

Endoglin (ENG) is a causative gene of type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have a higher prevalence of brain arteriovenous malformation (AVM) than the general population and patients with other HHT subtypes. The pathogenesis of brain AVM in HHT1 patients is currently unknown and no specific medical therapy is available to treat patients. Proper animal models are cr...

Background Different methods have been proposed to estimate Wall Shear Stress (WSS). Morgan and co-workers (J Thorac Cardiovasc Surg and Ann Biomed Eng 1998) used a finite difference scheme to quantify the WSS tensor. However, it is well known that finite-difference methods cannot effectively handle complex geometries, as those found in the cardiovascular system. To account for arbitrary cross-...

Hugh Griffiths holds the THALES/Royal Academy Chair of RF Sensors in the Department of Electronic and Electrical Engineering at University College London, England. From 2006–2008 he was Principal of the Defence Academy of Management and Technology. He received the MA degree in Physics from Oxford University in 1975, then spent three years working in industry, before joining University College L...

Book details Madhavan Guruprasad, Oakley Barbara, Kun Luis: Career Development in Bioengineering and Biotechnology, published by Springer, Series in Biomedical Engineering an official publication of the International Federation for Medical and Biological Engineering 2008 [http://www.springer.com/engineering/bio medical+eng/book/978-0-387-76494-8]. ISBN 978-0-38776494-8; DOI 10.1007/978-0-387-76...

Novel flocculants have been synthesized on the basis of glycogen. The efficiency of cationic glycogen can be explained in terms of Singh’s qualitative easy approachability model (EAM). The jar test was used previously to evaluate flocculation efficacy, but we have recently shown that a plot of interface height vs. settling times provides a better measure. In accord with the EAM, a one-to-one co...