Congenital diseases of dysmotility are a serious problem in children and, potentially, also in adults. Advances have recently been made in understanding one cause of pediatric dysmotility, Hirschsprung’s disease, which is the most visible congenital defect of the enteric nervous system (ENS). Although the diagnosis of Hirschsprung’s disease is sometimes missed, and the length of involved gut ma...

In this context, a novel structure has been proposed for simple Differential Evolutionary (DE) algorithm to solve optimal recloser placement. For this, an operator is added to DE algorithm to adapt concept of the problem. Other contribution of this work is formulating a novel objective function. The proposed objective function has been formulated to improve four reliability indices which consis...

In this context, a novel structure has been proposed for simple Differential Evolutionary (DE) algorithm to solve optimal recloser placement. For this, an operator is added to DE algorithm to adapt concept of the problem. Other contribution of this work is formulating a novel objective function. The proposed objective function has been formulated to improve four reliability indices which consis...

The avian enteric nervous system (ENS) consists of a vast number of unusually small ganglia compared to other peripheral ganglia. Each ENS ganglion at mid-gestation has a core of neurons and a shell of mesenchymal precursor/glia-like enteric neural crest (ENC) cells. To study ENS cell ganglionation we isolated midgut ENS cells by HNK-1 fluorescence-activated cell sorting (FACS) from E5 and E8 q...

Objectives: The goals of this investigation are to determine whether commercially available dose calibrators can be used to measure the activity of -emitting radionuclides used in pain palliation and to establish whether manufacturer-supplied calibration factors are appropriate for this purpose. Methods: Six types of commercially available dose calibrators were studied. Dose calibrator response...

BACKGROUND & AIMS Hirschsprung disease (HSCR) is caused by failure of cells derived from the neural crest (NC) to colonize the distal bowel in early embryogenesis, resulting in absence of the enteric nervous system (ENS) and failure of intestinal transit postnatally. Treatment is by distal bowel resection, but neural cell replacement may be an alternative. We tested whether aneuronal (aganglion...

Ischemic reperfusion injury (IRI) contributes to morbidity and mortality worldwide and results in a poor outcome for patients suffering from myocardial infarction. Ischemic post‑conditioning (IPostC), consisting of one or several brief periods of ischemia and reperfusion, generates powerful protection against IRI. The mechanism of IPostC initiation and development has previously been investigat...

AIM Preoperative detection of extranodal spread (ENS) in head and neck cancer can have important consequences for patient management. The aim of this study was to determine whether 18-fluorodeoxyglucose positron emission tomography ([18F]FDG PET) or a combination with Magnetic Resonance Imaging (MRI) could more accurately predict ENS, especially with the near availability of fully integrated [1...

Neurology is now well beyond being just a great specialty with a logical approach to a varied spectrum of interesting disorders. Gratifyingly, decades of nihilism in neurologic care have been replaced with a sense of buoyancy, as rapidly emerging data foster improved understanding of pathophysiology and resolve longstanding clinical equipoise surrounding many therapeutic interventions. Also, te...

[This document should not be cited in a published bibliography, and is supplied for the use of the recipient only]. Work carried out under contract to the Department of Energy This document should not be cited in a published bibliography except as 'personal communication' and is supplied for the use of the recipient only.