Endometriosis is a common benign gynecologic disorder, defined by endometrial glands and stroma outside of the endometrial cavity. The three primary types of endometriosis are superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis (DIE).Although laparoscopy continues to be the gold standard for the diagnosis of endometriosis, transvaginal ultrasonography show...

Leiomyomatosis peritonealis disseminata (LPD) is an extremely rare condition, which is characterized by the presence of multiple peritoneal and subperitoneal nodules composed of bland smooth muscle cells. Albeit extremely rare, coexistence of endometriosis within LPD lesions has also reported. Herein, we report the seventh documented case of LPD coexisting with endometriosis within the same les...

BACKGROUND Pelvic endometriotic lesions are often laden with hemosiderin. In order to investigate the potential source of such iron deposits, we examined whether the seric and erythrocyte fractions of menstrual effluent might influence the occurrence of iron deposition within lesions in a murine model of endometriosis. METHODS Endometriosis was induced in 57 nude mice by intraperitoneal injec...

Objective. The goal of this study was to explore the clinical value of combining two-dimensional (2D) and three-dimensional (3D) transvaginal contrast-enhanced ultrasounds (CEUS) in diagnosis of endometrial carcinoma (EC). Methods. In this prospective diagnostic study, transvaginal 2D and 3D CEUS were performed on 68 patients with suspected EC, and the results of the obtained 2D-CEUS and 3D-CEU...

Endometrial carcinoma (EC) is classified into a wide range of morphological variants; this list has expanded over the past decade with inclusion mesonephric-like and dedifferentiated as EC variants in fifth edition WHO Classification Female Genital Tumours, recognition that carcinosarcoma biphasic rather than sarcoma. Each variant distinct molecular abnormalities, including TCGA-based subtypes,...

: Females over 20 years of age come frequently to gynecological clinics, with the complaint Abnormal Uterine Bleeding (AUB). It has a direct impact on physical and mental health females. This research aims detect frequency different uterine causes AUB determine relationship between histopathological lesions associated their groups presentation. Endometrial biopsies / hysterectomy specimens were...

PURPOSE Endometrial carcinoma (EC) is common in the population and the most frequent extracolonic malignancy in hereditary nonpolyposis colorectal carcinoma (HNPCC)/Lynch syndrome. We characterized precursor lesions of endometrioid EC to identify markers of malignant transformation and tumor progression. EXPERIMENTAL DESIGN Serial specimens of normal endometrium, simple hyperplasia, complex h...

Diagnosis of endometrial intraepithelial neoplasia (EIN) requires learning new criteria. Two trainees rendered diagnoses based on biopsy findings, and then measured the effect of reviewing PAX2 on their interpretation. Fifty-two endometrial biopsy specimens diagnosed as having EIN were evaluated using EIN criteria. Background endometrial pattern, altered differentiation, and any features compli...

Endometriosis, a common cause of pelvic pain and female infertility, depends on the growth of vascularized endometrial tissue at ectopic sites. Endometrial fragments reach the peritoneal cavity during the fertile years: local cues decide whether they yield endometriotic lesions. Macrophages are recruited at sites of hypoxia and tissue stress, where they clear cell debris and heme-iron and gener...

Endometrial stromal tumors are reviewed with emphasis on their wide morphologic spectrum and problems in differential diagnosis, highlighting issues that have received particular attention in the recent literature. These neoplasms are divided into two major categories--endometrial stromal nodules and endometrial stromal sarcomas--a distinction made on the basis of the lack of significant infilt...