Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction. In this study, the aza-Michael addition step to generate intermediate enaminones was optimized presence of ytterbium triflate. Moreover, apart all reactants could be deployed almost equimolar ratios, which increases atom e...

The aim of the present study was to synthesize isoflavone-enaminones 3a-c and 7-alkoxy-isoflavones 4a-c, evaluate their inhibition ?-glucosidase, analyze bioisosteric effect presence versus absence aromatic moieties in these benzopyran derivatives. All test compounds exhibited greater ?-glucosidase than positive control acarbose. series isoflavones 4a-c showed higher inhibitory activity (IC50 =...

Depois de trinta e dois anos no Brasil e de aposentada da Universidade Estadual de Campinas, a autora gostaria de apresentar este resumo representando uma grande parte da pesquisa em metodologia sintética desenvolvida pelos grupos de pesquisa de Albert J. Kascheres e da autora no Instituto de Química da Universidade Estadual de Campinas. Contribuições foram feitas nas áreas de enaminonas, diazo...

A novel pyrazolo-enaminones, bipyrazoles and bipyrazolopyridines from 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione 4-methyl-2-phenyl-2H-pyrazolo[3,4-b]pyridine-3,6(3aH,7H)-dione have been synthesized by assisted heating with microwave radiation without any catalyst. The pyridine pyrazole ring formation has developed easily accessible enamino keto esters formylation followed i...

The fortuitous modification of a quinoline-proline-piperazine side chain linked to a steroid in the presence of lithium (trimethylsilyl) acetylide has generated an unknown product that is more active than its precursor. After having characterized two β-enaminones (two-carbon homologation compounds) that were generated from a simplified model side chain, we have identified the unknown product as...