The aim of present study was to prepare and characterize the recrystallized agglomerates of water insoluble non steroidal anti-inflammatory drug, indomethacin (IM) with hydrophilic polymers like polyvinyl pyrrolidone (PVP),hydroxyl ethyl cellulose (HEC) and hydroxyl propyl methyl cellulose (HPMC) by using emulsion solvent diffusion (ESD) technique for enhancing the solubility, dissolution rate,...

the present study involves preparation and evaluation of gastric-mucoadhesive microparticles with metformin hydrochloride as model drug for prolongation of gastric residence time. the microparticles were prepared by the emulsification solvent evaporation technique using polymers of carbomer 934p (c) and ethylcellulose (ec). the microparticles were prepared by emulsion solvent evaporation method...

The present investigation was aimed to formulate and evaluate the gastro-retentive floating microballoons of glipizide using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 (RS 100) by emulsion solvent evaporation technique. The floating microballoons were evaluated using micromeritic properties, buoyancy, in vitro drug release, scanning electron microscopy and stab...

This study proposes a new concept of pH-sensitive poly(lactide-co-glycolide) (PLGA) nanoparticle composite microcapsules for oral delivery of insulin. Firstly, insulin-sodium oleate complex was prepared by the hydrophobic ion pairing method and then encapsulated into PLGA nanoparticles by the emulsion solvent diffusion method. In order to reduce the burst release of insulin from PLGA nanopartic...

Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required. The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro. This study used the water-in-oil-in-water (w1/o/w2) double emulsion and solvent diffusion/evaporation...

The aim of this study was to prepare Spherical agglomerates of Carbamazepine by Quesi-Emulsion Solvent Diffusion system (QESDS) with Ethanol-Chloroform-Water system. Granules were prepared by wet granulation method with different excipients.The prepared agglomerates were evaluated for flowability, compressibility, wettability, packability and solubility. Tablets were prepared and evaluated for ...

We use diffusing-wave spectroscopy to measure the motion of droplets in concentrated emulsions subjected to a periodic shear strain. The strain gives rise to periodic echoes in the correlation function which decay with increasing strain amplitude. For a given strain amplitude, the decay of the echoes implies that a finite fraction of the emulsion droplets never rearranges under periodic strain ...

A multiple-unit oral floating system was prepared using the emulsification-solvent diffusion method to prolong the gastric emptying time of theophylline. For this purpose, theophylline, ethyl cellulose and dibutyl phthalate were dissolved in an ethanol/dichloromethane mixture, added to 0.1 M HCl containing NaCl (20%) or saturated theophylline and/or different concentrations of polysorbate 80 an...

In the present study controlled release formulation of Indomethacin microsponges were prepared by using Eudragit RS 100, pH independent release retardant polymer and PVA, stabilizer or emulsifier. Microsponges were prepared by Quasi emulsion solvent diffusion method by changing drug polymer ratio (3:1, 4:1, 5:1) and process was optimized. Microsponges were evaluated by micromeritic properties, ...