Spermiotoxic, embryotoxic and cytotoxic effects of the widely used biofouling biocide copper pyrithione (CuPt) were evaluated in bioassays to examine inhibition fertilization rate, offspring quality on early development sea urchin Paracentrotus lividus. CuPt was non-spermiotoxic for rates but frequency embryonic malformations increased a concentration-dependent manner when eggs fertilized with ...

Aflatoxin B1-contaminated feeds and foods induce various health problems in domesticated animals humans, including tumor development hepatotoxicity. B1 also has embryotoxic effects different livestock species humans. However, it is difficult to distinguish between the indirect, maternally-mediated toxic direct embryotoxicity of aflatoxin mammals. In present study, we investigated B1-induced a z...

We developed and optimized a screening procedure, in which zebrafish embryos were explored as a model for the evaluation of the specific embryotoxic and teratogenic potential of chemicals. A selection of known positive (retinoic acid, valproic acid, caffeine, lithium chloride) and negative (glucose, saccharin) compounds for developmental toxicity were used to evaluate this method. We exposed em...

would suggest that the enzyme responsible for mediumchain fatty acid activation is not active at this time. The lack of antagonism of salicylate and octanoate against the embryotoxic effects of valproate is also compatible with the mechanisms of teratogenicity and hepatotoxicity being fundamentally different. Although these data rule out one possibility, they provide little direct information o...

Rhizoma Atractylodes macrocephala, Radix Isatidis, Coptis chinensis and Flos Genkwa are common herbal remedies used by pregnant woman in China. In this study, their potential embryotoxicity was assessed using the embryonic stem cell test (EST) and a prediction model. The potential embryotoxicity of the herbs was based on three endpoints: the concentrations of the compounds that inhibited the pr...