D espite strong evidence implicating inflammation as a causal factor in some forms of depression, there are a number of issues to be resolved before this evidence can be translated into novel interventions. One such issue is the need to understand heterogeneity among individuals with inflammatory disorders and depression. In their report, Szigethy et al (1) described their attempt to tackle thi...

Background Increasing evidence suggests a pivotal role for neuronal inflammation in response to replicating varicella zoster virus in the development of postherpetic neuralgia (PHN). Objective In this study, we investigated the value of serum levels of various inflammatory markers in acute herpes zoster (HZ) as predictors for the development of PHN. Methods A total of 116 patients with acut...

Introduction: Primary diagnosis of infection can be made by serological inflammatory markers like erythrocytes sedimentation rate (ESR) and C-reactive protein (CRP). This study was planned to determine this normal temporal distribution ESR CRP in arthroplasty hemiarthroplasty Western Rajasthan.Materials Methods: Hospital based Observational Analytical conducted Tertiary care facility, Jodhpur f...

Aim: The aim of this study is to investigate some immuno-haematological characteristics of Nigerian sickle cell disease (SCD) patients in asymptomatic steady state. Material and Methods: Thirty asymptomatic SCD patients and 30 apparently healthy ageand sex-matched non-sickle cell disease individuals were investigated. The packed cell volume, white blood cells and differentials, and platelet cou...

Osteoarthritis (OA) is a low grade systemic inflammatory disease in which many inflammatory mediators are known to be elevated in the peripheric blood. Blood platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) are accepted as novel markers in many of the systemic inflammatory disorders, but have not been investigated in synovitis-free radiographic OA yet.The aim of this study was to ...

Serum homocysteine, folic acid, lipoprotein (a) (Lp(a)), fibrinogen, and C-reactive protein (CRP) concentrations and erythrocyte sedimentation rates (ESR) were measured in 52 patients with familial Mediterranean fever (FMF) during attack-free periods and in 30 healthy control subjects. Serum homocysteine levels were significantly higher in the FMF patients (median 17.8 microg/dl; range 5.6-80.8...

OBJECTIVE To determine the usefulness of plasma procalcitonin (PCT) measurement to suspect infectious etiology in febrile patients with systemic autoimmune disease. METHODS PCT, C-Reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell count (WBC) were measured in 44 consecutive inpatients with a diagnosis of systemic autoimmune disease and fever >38 masculine C. Aft...

INTRODUCTION Decreasing the diagnostic delay in axial spondyloarthritis (axSpA) remains a major challenge. Here, we assessed the value of serum inflammatory biomarkers to distinguish early axSpA from other pathologies in a large cohort of patients referred with early back pain. METHODS Serum c reactive protein (CRP), erythrocyte sedimentation rate (ESR) and calprotectin were determined in the...

INTRODUCTION Readily available laboratory tests are extremely useful in achieving a better understanding of diseases, and thereby, allow thoughtful management decisions to be made. The examination of peripheral blood smears usually provides excellent clues to the cause of the disease. The main objective of this study was to compare the haematological parameters of patients with non-alcoholic fa...

Immunoglobulin (Ig) G4 accounts for 4–6% of the total IgG in a healthy human. Several evidence-based studies have suggested that level IgG4 is significantly elevated autoimmune diseases, including rheumatoid arthritis (RA). The clinical significance RA with regard to disease activity, severity, and treatment response remains elusive. We consecutively recruited 174 patients from our rheumatology...