Electrochemotherapy is a new and promising approach in treatment of tumors employing locally applied high voltage d.c. electric pulses in combination with chemotherapeutic drugs. Increased permeability of the plasma membrane, induced by electric pUlses, enables the chemotherapeutic drugs to enter into the cytosol, thus potentiating their anti-tumor effectiveness. In most of the studies publishe...

BACKGROUND Cutaneous metastases may cause considerable discomfort as a consequence of ulceration, oozing, bleeding and pain. Electrochemotherapy has proven to be highly effective in the treatment of cutaneous metastases. Electrochemotherapy utilises pulses of electricity to increase the permeability of the cell membrane and thereby augment the effect of chemotherapy. For the drug bleomycin, the...

Electrochemotherapy (ECT) enhances the effectiveness of chemotherapeutic agents. First, intratumoral drugs are injected; then, short intense electric pulses are applied, which permeabilizes tumor cell membranes and allows the drug to reach significantly higher cell concentrations.

Electrochemotherapy is gaining popularity for the treatment of malignancies of companion animals due to its efficacy and low cost. In this paper, we describe the successful treatment of a recurring fibrosarcoma in a cat by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The cat's tumor did not recur over the following five months, however the cat did expe...

The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was implemented in vivo and in vitro for mapping electric current pulses of the same order of magnitude (j approximately 2500 A/m2) as in electrochemotherapy through T50/80 mammary carcinomas, B-16 melanomas and SA-1...

Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemo-therapy is a novel therapeutic option that ablates tumours with electrical current and simultaneously administered anticancer ...

• Nanopulses in combination with bleomycin or cisplatin successfully kill cells. are comparably effective as 8 × 100 ?s pulses electrochemotherapy. cause lower metal release from electrodes than pulses. Nanosecond electric have several potential advantages electroporation-based procedures over the conventional micro- and millisecond including low level of heating, reduced electrochemical reacti...

We describe herein what is to our knowledge the first reported case of an invasive cutaneous metastasis with unknown primary, electively treated solely with electrochemotherapy. We describe a female patient with a large, invasive and painful lesion in her hypogastric region, extending up to the pubic area. The cutaneous biopsy and instrumental and laboratory analyses, all failed to reveal the p...