نتایج جستجو برای: eif4e

تعداد نتایج: 1551  

2014
Jun Zheng Jiao Li Lina Xu Guiyuan Xie Qiuyuan Wen Jiadi Luo Duo Li Donghai Huang Songqing Fan

Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor rare throughout most of the world but common in Southeast Asia, especially in Southern China. The phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) by MAP kinase-interacting kinases (Mnk) on Ser-209 promotes cellular proliferation, survival, malignant transformation and metastasis. However, whether the altera...

Journal: :The EMBO journal 1998
M Ptushkina T von der Haar S Vasilescu R Frank R Birkenhäger J E McCarthy

Interaction between the mRNA 5'-cap-binding protein eIF4E and the multiadaptor protein eIF4G has been demonstrated in all eukaryotic translation assemblies examined so far. This study uses immunological, genetic and biochemical methods to map the surface amino acids on eIF4E that contribute to eIF4G binding. Cap-analogue chromatography and surface plasmon resonance (SPR) analyses demonstrate th...

2013
Blake A. Jacobson Saritha C. Thumma Joseph Jay-Dixon Manish R. Patel K. Dubear Kroening Marian G. Kratzke Ryan G. Etchison Bruce W. Konicek Jeremy R. Graff Robert A. Kratzke

BACKGROUND Aberrant cap-dependent translation is implicated in tumorigenesis in multiple tumor types including mesothelioma. In this study, disabling the eIF4F complex by targeting eIF4E with eIF4E-specific antisense oligonucleotide (4EASO) is assessed as a therapy for mesothelioma. METHODS Mesothelioma cells were transfected with 4EASO, designed to target eIF4E mRNA, or mismatch-ASO control....

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Kateryna Feoktistova Enkhee Tuvshintogs Angelie Do Christopher S Fraser

Elevated eukaryotic initiation factor 4E (eIF4E) levels frequently occur in a variety of human cancers. Overexpression of eIF4E promotes cellular transformation by selectively increasing the translation of proliferative and prosurvival mRNAs. These mRNAs possess highly structured 5'-UTRs that impede ribosome recruitment and scanning, yet the mechanism for how eIF4E abundance elevates their tran...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Alex Kentsis Ivan Topisirovic Biljana Culjkovic Ling Shao Katherine L B Borden

The eukaryotic translation initiation factor eIF4E is deregulated in many human cancers, and its overexpression in cells leads to malignant transformation. Oncogenic properties of eIF4E are directly linked to its ability to bind 7-methyl guanosine of the 5' mRNA. Here, we observe that the antiviral guanosine analogue ribavirin binds to eIF4E with micromolar affinity at the functional site used ...

Journal: :Molecular and cellular biology 2005
Mary Lynch Li Chen Michael J Ravitz Sapna Mehtani Kevin Korenblat Michael J Pazin Emmett V Schmidt

Translation initiation factor eukaryotic translation initiation factor 4E (eIF4E) plays a key role in regulation of cellular proliferation. Its effects on the m7GpppN mRNA cap are critical because overexpression of eIF4E transforms cells, and eIF4E function is rate-limiting for G1 passage. Although we identified eIF4E as a c-Myc target, little else is known about its transcriptional regulation....

Journal: :Plant physiology 2003
Valérie Nicaise Sylvie German-Retana Raquel Sanjuán Marie-Pierre Dubrana Marianne Mazier Brigitte Maisonneuve Thierry Candresse Carole Caranta Olivier LeGall

The eIF4E and eIF(iso)4E cDNAs from several genotypes of lettuce (Lactuca sativa) that are susceptible, tolerant, or resistant to infection by Lettuce mosaic virus (LMV; genus Potyvirus) were cloned and sequenced. Although Ls-eIF(iso)4E was monomorphic in sequence, three types of Ls-eIF4E differed by point sequence variations, and a short in-frame deletion in one of them. The amino acid variati...

2015
Lydia M. Castelli David Talavera Christopher J. Kershaw Sarah S. Mohammad-Qureshi Joseph L. Costello William Rowe Paul F. G. Sims Christopher M. Grant Simon J. Hubbard Mark P. Ashe Graham D. Pavitt

Translation initiation factor eIF4E mediates mRNA selection for protein synthesis via the mRNA 5'cap. A family of binding proteins, termed the 4E-BPs, interact with eIF4E to hinder ribosome recruitment. Mechanisms underlying mRNA specificity for 4E-BP control remain poorly understood. Saccharomyces cerevisiae 4E-BPs, Caf20p and Eap1p, each regulate an overlapping set of mRNAs. We undertook glob...

Journal: :The Biochemical journal 2002
Koji Tomoo Xu Shen Koumei Okabe Yoshiaki Nozoe Shoichi Fukuhara Shigenobu Morino Toshimasa Ishida Taizo Taniguchi Hiroshi Hasegawa Akira Terashima Masahiro Sasaki Yoshio Katsuya Kunihiro Kitamura Hiroshi Miyoshi Masahide Ishikawa Kin-ichiro Miura

The crystal structures of the full-length human eukaryotic initiation factor (eIF) 4E complexed with two mRNA cap analogues [7-methylguanosine 5'-triphosphate (m(7)GTP) and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)] were determined at 2.0 A resolution (where 1 A=0.1 nm). The flexibility of the C-terminal loop region of eIF4E complexed with m(7)GTP was significantly re...

2015
Christos Demosthenous Jing Jing Han Mary J. Stenson Matthew J. Maurer Linda E. Wellik Brian Link Kristen Hege Ahmet Dogan Eduardo Sotomayor Thomas Witzig Mamta Gupta

Deregulated mRNA translation has been implicated in disease development and in part is controlled by a eukaryotic initiation complex eIF4F (composed of eIF4E, eIF4G and eIF4A). We demonstrate here that the cap bound fraction from lymphoma cells was enriched with eIF4G and eIF4E indicating that lymphoma cells exist in an activated translational state. Moreover, 77% (110/142) of diffuse large B c...

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