This paper presents the Eclipse-11, a new six degree-offreedom parallel mechanism, which can be used as a basis for general motion simulators. The Eclipse-I1 is capable of x, y and z-axis translations and a, b and c-axis rotations. In particular, it has the advantage of enabling continuous 360-degree spinning of the platform. The computational procedures for forward and inverse kinematics of th...

DARPins (designed ankyrin repeat proteins) are a novel class of binding molecules with the potential to overcome limitations of monoclonal antibodies, hence allowing novel therapeutic approaches. DARPins are small, single domain proteins (14 kDa) which can be selected to bind any given target protein with high affinity and specificity. These characteristics make them ideal agonistic, antagonist...

• Almost any mammalian organ and cell type can succumb to oncogenic transformation, giving rise to a bewildering array of clinical outcomes. • The causes of cancer are many and varied, and include genetic predisposition, environmental influences, infectious agents and ageing. These transform normal cells into cancerous ones by derailing a wide spectrum of regulatory and downstream effector path...

This paper presents the Eclipse-II, a new six degree-offreedom parallel mechanism, which can be used as a basis for general motion simulators. The Eclipse-II is capable of x, y and z-axis translations and a, b and c-axis rotations. In particular, it has the advantage of enabling continuous 360-degree spinning of the platform. The computational procedures for forward and inverse kinematics of th...

Cell death plays an essential role in the development of tissues and organisms, the etiology of disease, and the responses of cells to therapeutic drugs. Here we review progress made over the last decade in using mathematical models and quantitative, often single-cell, data to study apoptosis. We discuss the delay that follows exposure of cells to prodeath stimuli, control of mitochondrial oute...

In the paper the dynamic properties of the internal motion of redundant manipulators are considered. The motion is decoupled into the end-effector motion and the internal motion. Next, the dynamic model of a redundant manipulator is derived. A special attention is given to the inertial properties of the system in the space where internal motion is taking place; we define a null space effective ...