This 2-day inaugural conference on prodrugs was presented by Pharmaceutical Education Associates and covered recent developments in prodrug techniques to solve delivery and targeting issues in drug discovery and development. The speakers were drawn from industry and academia, and the conference was attended mostly by researchers working in the pharmaceutical and biotechnology industries. A numb...

A quasi-equilibrium mass transport analysis has been developed to quantitatively explain the solubility-permeability interplay that exists when using cyclodextrins as pharmaceutical solubilizers. The model considers the effects of cyclodextrins on the membrane permeability (P(m)) as well as the unstirred water layer (UWL) permeability (P(aq)), to predict the overall effective permeability (P(ef...

The reflection, transmission spectra and the polarization transformation of linearly polarized waves in the ferrite-semiconductor multilayer structure are considered. In the long-wavelength limit, the effective medium theory is applied to describe the studied structure as a uniaxial anisotropic homogeneous medium defined by the effective permittivity and effective permeability tensors. The inve...

During carbon dioxide (CO2) injection process, overpressure within targeted reservoirs might occur because of changes in stress related to the CO2 pressure, which could lead to deformation of the surrounding rocks, including caprocks which are geological formations with low permeability overlying a CO2 storage reservoir. The understanding for impact of effective pressure (i.e., the difference b...

The permeability of coal is a critical parameter in estimating the performance of coal reservoirs. Darcy’s law describes the flow pattern that the permeability has a linear relationship with the flow velocity. However, the stress induced deformation and damage can significantly influence the gas flow pattern and permeability of coal. Coals from Songzao coalfield in Chongqing, southwest China we...

It has been observed that dynamo action occurs in the von-Kármán-Sodium (VKS) experiment only when the rotating disks and the blades are made of soft iron. The purpose of this paper is to numerically investigate the role of soft iron in the VKS dynamo scenario. This is done by using a mean-field model based on an axisymmetric mean flow, a localized permeability distribution, and a localized α e...

We report simultaneous measurements of the permeability and effective porosity of oil-reservoir rock cores using one-dimensional NMR imaging of the penetrating flow of laser-polarized xenon gas. The permeability result agrees well with industry standard techniques, whereas effective porosity is not easily determined by other methods. This NMR technique may have applications to the characterizat...

Simple, safe and effective permeability enhancers are crucial for successful non-invasive drug delivery methods. We seek local permeability augmentation mechanisms for integration into passive or active architectures in order to enable novel therapeutic delivery routes of the target drug while minimizing drug formulation challenges. This study explores the efficacy of hydrogen peroxide (HP) as ...

With significant increase of tomographic equipment power, demand for Prediction relative permeability prediction Predicting in porous media from digital image data. In this work, it is predicted three -phase relative permeabilities with co-applying Darcy’s and Stokes equations in two case studies, namely Bentheimer sandstone and Estaillades limestone which their micro-CT data files were downloa...