introduction: development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. blood brain barrier (bbb) opening is an important part of edema named as vasogenic brain edema. in this study, quantitative alterations of bbb permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. methods: two groups of male rats (ischemic and sh...

Background: Nitric oxide synthase (NOS) activity is increased during hypertension and cerebral ischemia. NOS inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (BBB) disruption and cerebral edema formation during stroke in acute hypertension. Here, we investigated the role of NOS inhibition in progression of edema formation and BBB d...

 Background: Diabetes is a common metabolic disorder leading to the development of many complications, among which diabetic retinopathy and macular edema are the most significant. These complications can contribute to blindness if not diagnosed or treated properly, and several studies have been conducted to evaluate the methods for the prevention or slowing down their progression. Ther...

purpose: to determine the effect of grid pattern laser photocoagulation on diabetic diffuse macular edema with assessment of visual outcome. patients & methods: the author reviewed the medical records of 84 eyes of 62 patients with diabetic diffuse macular edema treated with grid pattern green argon laser photocoagulation in farabi eye hospital between the years 1992-1995, the follow-up period ...

background: rheumatoid arthritis is a type of inflammatory pain and is an autoimmune and chronic inflammatory disease which can lead to hyperalgesia, edema and decreased motor activity in affected area. mesenchymal stem cells conditioned medium (msc-cm) has anti-inflammatory mediators which can regulate the immune responses, alleviate inflammatory symptoms and has a paracrine effects too. the a...

background: to extract utility values of diabetic retinopathy on a perfect health and perfect vision scales for iranians with both types diabetes. methods: in this investigation, 150 untreated patients with diabetic retinopathy consecutively were examined and interviewed in farabi eye hospital, tehran, iran, a tertiary referral center in the iranian health care system. utility values based on p...

purpose: to evaluate the effect of intravitreal triamcinolone acetonide (ivt) reinjection on clinical and optical coherence tomographic (oct) features in refractory diabetic macular edema (dme). methods: in an interventional case series, all ivt-treated patients enrolled in a previous clinical trial (45 subjects), were recalled for performing a new ophthalmologic examination and oct. suitable e...

purpose: to evaluate the effect of intravitreal triamcinolone acetonide (ivt) on clinical, angiographic, and optical coherence tomographic parameters in refractory diabetic macular edema (dme). methods: in a double-masked placebo-controlled randomized clinical trial, 88 eyes of 61 patients with dme refractory to previous laser therapy or not suitable for such treatment were included in the stud...

objective(s): brain edema is one of the most serious causes of death within the first few days after trauma brain injury (tbi). in this study we have investigated the role of shilajit on brain edema, blood-brain barrier (bbb) permeability, intracranial pressure (icp) and neurologic outcomes following brain trauma.   materials and methods: diffuse traumatic brain trauma was induced in rats by dr...