In 1991, a group of expert scientists at a Wingspread work session on endocrine-disrupting chemicals (EDCs) concluded that "Many compounds introduced into the environment by human activity are capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Endocrine disruption can be profound because of the crucial role hormones play in controlling development." Sin...

The co-existence of free and conjugated estrogens and the interference from complex matrices often lead to largely variable detected concentrations and sometimes even negative removal efficiencies of typical endocrine disrupting chemicals (EDCs) in wastewater treatment plants (WWTPs). In this study, a highly selective and sensitive method was developed for simultaneous extraction, elution, and ...

There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. In this first Scientific Statement of The Endocrine Society, we present the evidence t...

Polycystic ovary syndrome (PCOS) is one of the most common and complex endocrinopathies among reproductive-age women. Polycystic ovary syndrome is characterized by symptomatology of oligomenorrhea and androgen excess, with or without presence of polycystic ovarian morphology. The etiology of PCOS is multifactorial, including genetic and environmental components. It has been previously establish...

The presence and distribution of endocrine-disrupting chemicals (EDCs) in the mariculture fish from Pulau Kukup, Johor Malaysia have been studied along with impact on human health. Six different species were collected, due to their high consumption Asian region—especially Malaysia, assess levels EDCs. highest concentration EDCs detected muscle was dexamethasone (2.37–15.84 ng/g) (0.77–13.41 ng/...

Endocrine-disrupting chemicals (EDCs) present in aquatic environment have been regarded as detrimental organic pollutants that pose significant adverse impacts on human health and the ecosystem. The removal of EDCs is highly desired to mitigate their harmful effects. Physical treatment through membrane-based separation processes an attractive approach, it can effectively remove a wide range rec...

OBJECTIVE Endocrine-disrupting chemicals (EDCs) adversely affect human health. Our objective was to determine the association of EDC exposure with earlier age of menopause. METHODS Cross-sectional survey using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2008 (n = 31,575 females). Eligible participants included: menopausal women >30 years of age; not currently p...

BACKGROUND Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult. OBJECTIVE Our goal was to identify gestational EDC exposures associated with autistic behaviors. METHODS We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PC...

Endocrine disrupting chemicals (EDCs) interfere with the biosynthesis, metabolism, and functions of steroid hormones, including estrogens and androgens. Aromatase enzyme converts androgen to estrogen. Thus, EDCs against aromatase significantly impact estrogen- and/or androgen-dependent functions, including the development of breast cancer. The current study aimed to develop a biologically relev...

Abstract Type 2 diabetes mellitus (T2DM), one of the most common chronic metabolic diseases, involves a complex interaction among genetic, epigenetic, and environmental risk factors. The incidence prevalence T2DM are rapidly increasing globally. In recent years, body evidences from both human animal studies have displayed an association between exposure to early unfavorable life factors such as...