Defects in a developmental signaling pathway involving mammalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedgehog (shh), contribute to tumor formation in several tissues. Recently, a subset of medulloblastoma, the most common malignant brain tumor in children, was found to contain somatic mutations in the human ptc gene. In addition, basal cell ne...

INTRODUCTION    Papillary thyroid carcinoma (PTC) is a well‑differentiated tumor that occurs in several histological variants whose biological behaviors remain unclear. Angiogenesis and lymphangiogenesis are critical processes that enable tumor progression. OBJECTIVES    The aim of this study was to evaluate the angiogenic and lymphangiogenic phenotypes of PTC, considering the differences betwe...

INTRODUCTION Several studies have reported a high frequency of papillary thyroid cancer (PTC) in patients with acromegaly. The aim of this study was to determine the prevalence and predictors of thyroid cancer in patients with acromegaly and to investigate the frequency of the BRAFV600E mutation in PTC patients with and without acromegaly. MATERIALS AND METHODS We conducted a retrospective st...

background: there are inter-observer disagreements between papillary thyroid carcinoma (ptc) with other follicular lesions of thyroid in aspect of diagnosis. cd56 is present on follicular epithelial cells of the normal thyroid. we evaluated the diagnostic value of cd56 expression in ptc, follicular thyroid lesions, and follicular thyroid neoplasms. materials and methods: seventythree cases diag...

The health problems caused by the frequent relapse of papillary thyroid carcinoma (PTC) remain a worldwide concern since morbidity rate PTC ranks highest among cancers. Residues from contralateral central lymph node metastases (con-CLNM) are key reason for persistence or recurrence unilateral (uni-PTC); however, ability to assess status con-CLNM in uni-PTC patients is limited. To clarify risk f...

Abstract Introduction: Maxillary canines commonly have an ectopic eruption. This study aimed to assess the factors related to the ectopic maxillary permanent canines. Materials and Methods:This was a descriptive cross-sectional study of 1357 panoramic radiographs from patients 8 to 13 years old. The radiography was excluded if the patient had any developmental disease or if the panoramic im...

In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus. Docking experiments between the ancestral PTC and tRNAs sugg...

In this study we investigated whether in plants, like in mammals, components of the nuclear cap-binding protein complex (CBC) are involved in nonsense-mediated mRNA decay (NMD). We selected several genes producing at least two alternatively spliced mRNA variants: one with a premature termination codon (PTC+) and another without it (PTC-). For each gene the PTC+/PTC- ratio was calculated using R...

BACKGROUND/AIMS To characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease. METHODS Medical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without Graves' disease were analyzed retrospectively. A diagnosis of PTC was based on a pathologic examination. RESULTS The frequency of hypoechogenicity ...

OBJECTIVE Papillary thyroid carcinoma (PTC) sometimes occurs with Hashimoto's thyroiditis (HT). It is often difficult to differentiate between benign and malignant nodules in HT because HT varies greatly on ultrasonography. We aimed to characterize the ultrasonographic features of PTC with HT. PATIENTS AND METHODS In this retrospective study, 2167 patient records (1897 women and 270 men) were...