[PDF] [Full Text] [Abstract] , March 28, 2007; 27 (13): 3548-3559. J. Neurosci. W. J. Kargo, B. Szatmary and D. A. Nitz Action-Reward Contingencies Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in [PDF] [Full Text] [Abstract] , November 7, 2007; 27 (45): 12176-12189. J. Neurosci. A. Johnson and A. D. Redish Point Neural Ensembles in CA3 Transiently Encode P...

Due to the potentially lethal effects of potent hERG inhibition, in silico approaches which can identify potent (IC50 < 1 μM) inhibitors are of considerable interest to the pharmaceutical industry [1]. We present recent work [2] in which in silico binary classifiers were trained to discriminate potent inhibitors from compounds exhibiting weaker (IC50 ≥ 1 μM) inhibition. Initial models were base...

Increased levels of oxidative stress (OS) in the brain have been linked to the etiology of several neurodegenerative diseases, e.g., Alzheimer’s and Parkinson’s disease (Navarro and Boveris, 2009; Melo et al., 2011; Radak et al., 2011; Sultana et al., 2013). A possible cause of increased OS levels is an imbalance in the omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) (Kiecol...

Annular pancreas, the second most common anomaly of the pancreas, is the development of a ring of pancreatic tissue that surrounds and often embraces the duodenum. It was first described by Tiedelmann in 1818 and named “annular pancreas” by Ecker in 1862 [1]. It is usually present in childhood, with symptoms due to duodenal obstruction. In 50% of cases, clinical manifestations become visible af...

An analysis of heat transfer in the flow of a viscous, in-compressible fluid along an infinite porous plate is presented when the plate is subjected to a transverse sinusoidal suction. The flow field becomes three-dimensional due to this type of suction velocity. Expressions for the flow and temperature fields are obtained by series expansion method. It is found during the course of discussion ...

With the popularization of smartphones, various smartphone centric ubiquitous sensing applications, which use a smartphone in conjunction with external sensors for data acquisition, processing, display, communication, and storage, have emerged. Because smartphones do not have a universal data interfaces, many ubiquitous sensing applications use the earphone and the microphone channels of the 3....

It is generally agreed that normal spinal fluid is entirely devoid of complement, but the reports of its presence in the spinal fluid in cerebrospinal diseases are contradictory. Complement was found in the spinal fluid of all cases of meningococcus meningitis by Ward and Fothergill (1), but was reported to be absent in the same diseases by others (24). Ward et al. (1, 5) found complement to be...

This paper has a two-fold purpose: first, to present the signs and symptoms of atrial septal defect and thus outline the findings that help in making the clinical diagnosis, and secondly, to show that correct and early diagnosis is important, because this anomaly gives rise to serious, although frequently obscured, symptoms and disabilities more often than has been generally realized. Clinicall...