•To consider differential diagnosis for multiple ring enhancing lesions in an immunocompromised patient.•To highlight the characteristic imaging features of toxoplasmosis: ‘‘concentric and eccentric target signs’’.•To radiologically demonstrate intracranial course oculomotor nerve its nucleus.•To lay stress on rare causes Weber’s syndrome: Cerebral toxoplasmosis our case. A 25-year-old male, HI...

A 9-year-old girl presented with a firm occipital swelling. She had multiple café-au-lait lesions without other clinical features or family history of neurofibromatosis type 1 (NF1). MRI showed subcutaneous soft tissue mass in the left occipitotemporal region with “target sign” suggestive of plexiform neurofibroma (figure 1). There were supra and infratentorial T2-weighted hyperintense lesions,...

Hepatitis B virus (HBV) is a DNA virus that infects the liver as primary target. Currently, a high affinity receptor for HBV is still unknown. The dendritic cell specific C-type lectin DC-SIGN is involved in pathogen recognition through mannose and fucose containing carbohydrates leading to the induction of an anti-viral immune response. Many glycosylated viruses subvert this immune surveillanc...

Hepatitis C virus (HCV) is a major health problem. However, the mechanism of hepatocyte infection is largely unknown. We demonstrate that the dendritic cell (DC)-specific C-type lectin DC-SIGN and its liver-expressed homologue L-SIGN/DC-SIGNR are important receptors for HCV envelope glycoproteins E1 and E2. Mutagenesis analyses demonstrated that both HCV E1 and E2 bind the same binding site on ...

We solve the equations of two-dimensional hydrodynamics describing a circumbinary disk accreting onto an eccentric, equal-mass binary. compute time rate change binary semimajor axis $a$ and eccentricity $e$ over continuous range eccentricities spanning $e=0$ to $e=0.9$. find that binaries with initial $e_0 \lesssim 0.1$ tend $e=0$, where expands. All others are attracted $e \approx 0.4$, decays...

Fusion of the human immunodeficiency virus (HIV) to the plasma membrane of target cells is mediated by interaction of its envelope glycoprotein, gp120, with CD4 and appropriate chemokine receptors. gp120 additionally binds to DC-SIGN, a C-type lectin expressed on immature dendritic cells. This interaction does not result in viral fusion, but instead contributes to enhanced infection in trans of...

Attentional selectivity in touch is modulated by the position of the body in external space. For instance, during endogenous attention tasks in which tactile stimuli are presented to the hands, the effect of attention is reduced when the hands are placed far apart than when they are close together and when the hands are crossed as compared to when they are placed in their anatomical position. T...

Recent increases in the discovery of high multiplicity Sub-Jovian planetary systems, in addition to discoveries of giant planets of high eccentricities in these multiple body systems, lead to questions into their origins and evolution. The study of secular interactions is not new, however it has only recently been applied to exoplanetary systems. These systems sometimes fall far from the classi...