BACKGROUND The Ecballium elaterium trypsin inhibitor (EETI-II), a 28-amino acid member of the knottin family of peptides, contains three interwoven disulfide bonds that form multiple solvent-exposed loops. Previously, the trypsin binding loop of EETI-II has been engineered to confer binding to several alternative molecular targets. Here, EETI-II was further explored as a molecular scaffold for ...

A tanulmány 44 neofiton faj 272 új elterjedési adatát tartalmazza Magyarország területéről az elmúlt néhány évből. Először sikerült kimutatni Magyarországról Iris orientalis-t, melynek meghonosodott populációját találtuk kiszáradt, sztyeppesedő mocsárréten. közelmúltban megtelepedett, de vélhetően vasút mentén gyorsan terjedő lesz a Lepidium oblongum. Kerti szökevényként Buddleja davidii és Bro...

Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Hence, antibacterial activities of ethanolic extracts of 19 plant species were studied against multi-drug resistant clinical isolates using agar well diffusion method. Extracts of Liquidambar orientalis, Vitis vinifera,?? ?????????????????????? ????????????????????,...

BACKGROUND Cystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents. For this purpose, previous protein engineering efforts have focused on knottins based on the Ecballium elaterium trypsin inhibitor (EETI) from squash seeds, the Agouti-related protein (AgRP) neuropeptide from mammals,...

BACKGROUND One of the biggest obstacles to progress in traditional Chinese medicine (TCM) development in Western countries is the difficulty of applying the traditional concepts to the Western medicinal plants, which are not traditionally described in ancient literature. During recent years, new advances in the field of understanding Yin/Yang aspects from a modern bioscientific point of view ha...

UNLABELLED BACKGROUND In Europe, only a limited number of cross-cultural comparative field studies or meta-analyses have been focused on the dynamics through which folk plant knowledge changes over space and time, while a few studies have contributed to the understanding of how plant uses change among newcomers. Nevertheless, ethnic minority groups and/or linguistic "isles" in Southern and E...

Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Hence, antibacterial activities of ethanolic extracts of 19 plant species were studied against multi-drug resistant clinical isolates using agar well diffusion method. Extracts of Liquidambar orientalis, Vitis vinifera,?? ?????????????????????? ????????????????????,...

Nowadays, increasing in prevalence of multiple drug resistance implies the development of new synthetic antibacterial, antioxidative and anti-inflammatory drugs from alternative sources (Papadoupoulo et al., 2005). Therefore, there is a renewed interest in natural substances containing phytoconstituents that exhibited several biological properties. They are used in health to prevent oxidative d...