Over the last several hundred years, local and national educational systems have evolved from relatively simple systems to incredibly complex, interdependent, policy-laden structures, to which many question their value, effectiveness, and direction they are headed. System Dynamics is a field of analysis used to guide policy and system design in numerous fields including business and urban plann...

Muscle-specific kinase (MuSK) is a crucial receptor tyrosine kinase required for the development and function of neuromuscular junction. Although many domains of the protein have already been modeled with crystallographic techniques in various organisms, a single model for the whole human structure is not yet available. We have tried to predict a complete model of the protein, by using two para...

We consider nanometer-sized fluid annuli (rings) deposited on a solid substrate and ask whether these rings break up into droplets due to the instability of Rayleigh-Plateau-type modified by the presence of the substrate, or collapse to a central drop due to the presence of azimuthal curvature. The analysis is carried out by a combination of atomistic molecular dynamics simulations and a contin...

despite a quite short early history, computational drug design and discovery methods can now be efficient in reducing costs and speeding up drug developing procedure. melanocortin-4 receptor (mc4r) is a g protein-coupled receptor implicated in the regulation of body weight. despite its clinical reputation, there is a lack of in-depth knowledge about structure and behavior of mc4r in lipid bilay...

abstract in the dynamic and competitive market, managers seek to find effective strategies for new products development. since there has not been a thorough research in this field, this study is based on a review on the risks exist in the npd process and an analysis of risks through fmea approach to prioritize the existent risks and a modeling behavior of the npd process and main risks using sy...

in this article, dynamics of the cerebrospinal fluid (csf) was studied, using computational fluid dynamics. using mri images of two special cases, a 2-dimensional model of the ventricular system was made. csf velocity and pressure distribution in ventricular system have high importance since the flow pattern of this liquid has an important effect on intracranial pressure, i.e., icp, which has a...

Protein kinases work because their flexibility allows to continuously switch from inactive to active form. Despite the large number of structures experimentally determined in such states, the mechanism of their conformational transitions as well as the transition pathways are not easily to capture. In this regard, computational methods can help to shed light on such an issue. However, due to th...

CFD (Computational Fluid Dynamics) simulation is the main research method for assessing the wind environment around building complexes. Recent research showed the importance of turbulence models used in simulation and different turbulence models were developed to improve the precision of CFD simulation results. In this paper, a comparison of different turbulence models in simulating wind enviro...

A molecular modeling strategy is proposed to describe the temperature (T) dependence of solubility parameter (δ) for the amorphous polymers which exhibit glass-rubber transition behavior. The commercial forcefield "COMPASS" is used to support the atomistic simulations of the polymer. The temperature dependence behavior of δ for the polymer is modeled by running molecular dynamics (MD) simulatio...