OBJECTIVE: Compression/thinning of the endometrial thickness with effect progesterone during luteal phase menstrual cycle is defined as compaction. This study aimed to show changes in intrauterine insemination cycles on pregnancy outcomes. STUDY DESIGN: Fifty-eight patients who were planned for included this prospective cohort study. The change between patients' measurements day trigger and 7th...

Background: Preterm labor remains one of the major cause neonatal morbidity and mortality. Different tocolytics have been studied for prolongation pregnancy, role progesterone in increasing latency period controversial. Aim study was to compare efficacy nifedipine with along dydrogesterone as a tocolytic agent case preterm find its impact on maternal outcome. Methods: This conducted 100 women w...

The objective: to substantiate and evaluate the improvement of pre-gravida preparation in women with a history combined infertility factors. Materials methods. We examined 102 who were diagnosed two factors simultaneously – tubal origin associated anovulation caused by hyperprolactinemia polycystic ovary syndrome. All patients divided into groups according three-month regimen: 1st group (52 wom...

Many surgical and non-surgical interventions are used in the management of threatened and recurrent miscarriages. Evidence-based management of recurrent miscarriages requires investigations into the underlying aetiology. When a specific cause is identified, directed treatment may reduce miscarriage rates. Combined aspirin and heparin for antiphospholipid syndrome, and screening and treatment of...

Stimulated IVF cycles are associated with luteal phase defect. In order to overcome this, different doses, durations and types of luteal phase support (LPS) have been evaluated. There is still no agreement regarding the optimal supplementation scheme. The aim of this paper is to assess the past and the current clinical practices of luteal supplementation in IVF. The databases of Medline and Pub...

INTRODUCTION The aim of this study was the long-term prospective evaluation of the effects of estroprogestagen (EP) therapy on the bone mineral density (BMD) of girls with functional hypothalamic amenorrhea (FHA) carrying various PvuII and XbaI polymorphisms of ER-α. MATERIAL AND METHODS Prospective observation included 84 FHA girls and 50 controls. The FHA patients were subjected to 4-year s...

Estrogens, both endogenous and exogenous, lower the fasting levels of the independent risk factor for cardiovascular disease homocysteine. The mechanism behind this observation remains unclear. In a randomized, placebo-controlled, double-blind study, 25 postmenopausal women with a screening homocysteine concentration above 10 micromol/liter were included. We investigated the influence on homocy...

One of the most remarkable immunological regulations is the maternal immune tolerance toward the fetal semiallograft during pregnancy, which has been referred to as immunity's pregnant pause. Rejection of the semiallogeneic trophoblast cells must be selectively inhibited and pathways presumably include Th2 cytokines unopposed by Th1 cytokines. Steroid hormones, including progesterone, have simi...

In this issue you will find an Opinion article by three icons of endometri-osis (Brosens et al., 2013). They present their ideas on the early stages of disease, in adolescents. Although there exists very little robust evidence to support many of their claims (as they recognize themselves), we decided to publish their manuscript to draw attention to the complex issue of preventive reproductive h...