Epidemic investigations reveal an intimate interrelationship between pain and depression. The effect of electroacupuncture (EA) on pain or depression has been demonstrated individually, but its effect on pain-depression dyad is unknown. Our study aimed to screen a dominant EA frequency on pain-depression dyad and determine the validity of acupoint selection based on meridian theory. The pain-de...

Chikungunya virus is the pathogenic alphavirus that causes chikungunya fever in humans. In the last decade millions of cases have been reported around the world from Africa to Asia to the Americas. The alphavirus nsP2 protein is multifunctional and is considered to be pivotal to viral replication, as the nsP2 protease activity is critical for proteolytic processing of the viral polyprotein duri...

The CD40-CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune responses and has therefore an essential role in the development of inflammatory diseases, including multiple sclerosis (MS). In MS, CD40 and CD40L are expressed on immune cells present in blood and lymphoid organs, affected resident central nervous system (CNS) cells, and inflammatory cells that...

Prior investigators have asserted that certain group characteristics cause group members to disregard outside information and that this behavior leads to diminished performance. We demonstrate that the very process of making a judgment collaboratively rather than individually also contributes to such myopic underweighting of external viewpoints. Dyad members exposed to numerical judgments made ...

This paper presents a new corpus, the Personality Dyads Corpus, consisting of multimodal data for three conversations between three personality-matched, two-person dyads (a total of 9 separate dialogues). Participants were selected from a larger sample to be 0.8 of a standard deviation above or below the mean on the Big-Five Personality extraversion scale, to produce an Extravert-Extravert dyad...

RATIONALE Single-tilt tomograms of the dyads in rat ventricular myocytes indicated that type 2 ryanodine receptors (RYR2s) were not positioned in a well-ordered array. Furthermore, the orientation and packing strategy of purified type 1 ryanodine receptors in lipid bilayers is determined by the free Mg2+ concentration. These observations led us to test the hypothesis that RYR2s within the mamma...

New classes of synthetic chlorin and bacteriochlorin macrocycles are characterized by narrow spectral widths, tunable absorption and fluorescence features across the red and near-infrared (NIR) regions, tunable excited-state lifetimes (<1 to >10 ns) and chemical stability. Such properties make dyad constructs based on synthetic chlorin and bacteriochlorin units intriguing candidates for the dev...

A series of field studies focused on the role of similarity as niche construction in friendships. Using a free-range dyad harvest method, we collected 11 independent samples with 1,523 interacting pairs, and compared dyad members' personality traits, attitudes, values, recreational activities, and alcohol and drug use. Within-dyad similarity was statistically significant on 86% of variables mea...

BACKGROUND Associations of eating behaviors and psychological profile between mothers and daughters with eating disorders exist, but it is important to dissect the influence of the mother in each specific disorder since all eating disorders must be seen or treated not as one entity. The aim of the present study was to evaluate the association of eating behavior and psychological profile between...