Methods The data derive from a total of 40 experiments on rats studied with approval of the local animal care and use committee. Pravastatin (0.2 mg/kg) or NaCl were injected subcutaneously 18 h prior to sepsis induction (colon ascendens stent peritonitis) or sham operation. 24 h after induction of sepsis the animals were re-laparotomized under general anaesthesia and received ongoing fluid rep...

Background and Aim: To investigate the radiopacity of different luting, lining and filling dental cements used in prosthetic dentistry in comparison with human and bovine dental hard tissues. Material and methods: Eight cylindrical samples of each material (6 x 1 mm) were prepared from Aqualox (APC), Durelon (DE) and Adhesor Carbofine (ACF) zinc polycarboxylate cements, Cavex zinc oxide eugenol...

In this article we introduce a new procedure for estimating population parameters under inequality constraints (known as order restrictions) when the unrestricted maximum liklelihood estimator (UMLE) is multivariate normally distributed with a known covariance matrix. Furthermore, a Dunnett-type test procedure along with the corresponding simultaneous confidence intervals are proposed for drawi...

Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution...

The multiplicity problem arises when several inferences are considered simultaneously as a group. If each inference has a 5% error rate, then the error rate over the entire group can be much higher than 5%. This article shows practical examples of multiple comparisons procedures that control the error of making any incorrect inference. The multcomp package for the R statistical environment allo...

Generally, multiple statistical analysis methods can be applied for certain kind of data, and conclusion could differ, depending on the selected statistical method. Therefore, it is necessary to fully understand the performance of each statistical method and to examine which method is appropriate to use and to standardize statistical methods for toxicity studies to be carried out routinely. Sev...

This article suggests a unified framework for testing Proof of Concept (PoC) and estimating a target dose for the benefit of a more comprehensive, robust and powerful analysis in phase II or similar clinical trials. From a pre-specified set of candidate models, we choose the ones that best describe the observed dose-response. To decide which models, if any, significantly pick up a dose effect, ...

The purpose of this study was to investigate the effect of different surface treatments on shear bond strength of saliva-contaminated resin-resin interfaces. Flat resin surfaces were fabricated. In the control group, no contamination or surface treatment was performed. The resin surfaces of the experimental groups were contaminated with saliva and air-dried, and then submitted to: (G1) rinsing ...

OBJECTIVE To compare different surface treatments of lithium disilicate-based ceramic on bond strengths to composite. METHODS Lithium disilicate-based ceramic microbars (1 mm × 1 mm × 6 mm) were produced and abraded using diamond (D) or CoJet sandblasting (C), etched using phosphoric acid (P) or hydrofluoric acid (H) and silanised (S). A total of 12 surface treatments were adopted: D, DP, DH,...

Root canal irrigation is an important adjunct to control microbial infection. The aim of this study was to investigate the effect of 2.5% (wt/vol) sodium hypochlorite (NaOCl) agitation on the removal, killing, and degradation of Enterococcus faecalis biofilm. A total of 45 root canal models were manufactured using 3D printing with each model comprising an 18 mm length simulated root canal of ap...