نتایج جستجو برای: druggability
تعداد نتایج: 302 فیلتر نتایج به سال:
TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets...
inhibitors has not been possible, perhaps for a combination of reasons, including challenges in function-based screening assays and the intrinsic refractoriness of aquaporins to drug discovery (termed non-druggability). One area of recent progress is in AQP4-based therapeutics for neuromyelitis optica. The idea is to block the binding of pathogenic autoantibodies to astrocyte AQP4, which may pr...
Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the impermeable nature of BBB against effective delivery of biologics. Indeed, it is...
To develop methodology to predict the potential druggability of middle molecules, we examined structure, solubility, and permeability relationships a diverse library (HKDL ver.1) consisting 510 molecules (359 natural product derivatives, 76 non-natural products, 46 29 derivatives). The included peptides, depsipeptides, macrolides, lignans, 476 compounds had molecular weight in range 500–2000 Da...
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