Introduction Malaria is a common tropical infection. It is a kind of mosquito borne infection. The pathogen is the protozoa in Plasmodium spp. The patient usually gets acute febrile illness after get mosquito bite at malarial area. The infection can still be seen in several countries. The cases can be presently seen not only in tropical but nontropical countries due to good transportation syste...

The emerging field of toxicoproteomics has been greatly advanced by quantitative proteomic technologies and their increasing applications in toxicology. The discipline is focused on the proteomic study of toxicity caused by toxic substances, including but not limited to drugs, toxins, environmental stressors, chemicals and any other materials that induce significant pathological responses. Drug...

Antimalarial drug toxicity is viewed differently depending upon whether the clinical indication is for malaria treatment or prophylaxis. In the treatment of Plasmodium falciparum malaria, which has a high mortality if untreated, a greater risk of adverse reactions to antimalarial drugs is inevitable. As chloroquine resistance has become widespread, alternative agents may be used in treatment re...

introduction: previous studies have raised the probably of cardiac manifestation in tramadol poisoning. however, conclusive information on electrocardiographic (ecg) abnormalities of tramadol overdose remains to be explained. therefore, the present study aimed to evaluate the epidemiology of ecg abnormalities in tramadol poisoned patients. methods: in a prospective cross-sectional study, all pa...

Background: Chloroquine is a 4-aminoquinoline derivative. Initially the substance was used as an antimalarial drug, but now chloroquine also to treat connective tissue diseases. It widely drug in rheumatological diseases, especially rheumatoid arthritis and systemic lupus erythematosus. A number of side effects have been reported public literature among patients using this drug. This article re...

Objective(s): Nanocarriers are drug delivery vehicles, which have attracted the attention of researchers in recent years, particularly in cancer treatment. The encapsulation of anticancer drugs using protein nanocages is considered to be an optimal approach to reducing drug side-effects and increasing the bioavailability of anticancer drugs. Epirubicin (EPR) is an active chemotherapeutic medica...

Evaluation of drug toxicity is necessary for drug safety, but in vivo drug absorption is varied; therefore, a rapid, sensitive and reliable method for measuring drugs is needed. Zebrafish are acceptable drug toxicity screening models; we used these animals with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method in a multiple reaction monitoring mode to quantify drug uptake in ze...

Adverse drug reactions that cannot be predicted from the pharmacological properties of the drug and which are not easily reproduced in laboratory animals are a major complication of drug therapy. It is necessary to investigate the mechanisms of such reactions in order to (1) define structural features within a given drug molecule which are responsible for causing toxicity and (2) to identify th...

OBJECTIVE Antiretroviral drugs can prevent mother-to-child transmission of HIV infection, but in-utero antiretroviral exposure may be associated with neurologic symptoms due to mitochondrial toxicity. We sought to identify the currently recommended regimen to prevent mother-to-child transmission that optimally balances risks of pediatric HIV infection and neurologic mitochondrial toxicity. DE...