Cystic fibrosis (CF) is rare in Japan. We encountered a CF case with drug-resistant Pseudomonas aeruginosa infection and successfully performed lung transplant from living related donors. A combination of beta-lactams and aminoglycosides for drug-resistant P. aeruginosa infection was administered before lung transplantation. Intravenous colistin was also used immediately before and after transp...

Abstract Treatment of bacterial infections with broad-spectrum antibiotics is a strategy severely limited by the decreased ability perturbed resident microbiota to control expansion antibiotic-resistant pathogens. Live biotherapeutic products (LBPs) could provide an alternative in infection restoring gut colonization resistance and controlling resistant strains, important therapeutic need not b...

OBJECTIVE To investigate the in vitro and in vivo antibacterial activities of tigecycline and other 13 common antimicrobial agents, alone or in combination, against multi-drug resistant Acinetobacter baumannii. METHODS An in vitro susceptibility test of 101 A. baumannii was used to detect minimal inhibitory concentrations (MICs). A mouse lung infection model of multi-drug resistant A. baumann...

Objectives: To determine the frequency of Escherichia coli (E. Coli) with multi-drug resistance and sensitivity to oral Fosfomycin in urinary tract infections a public sector hospital Peshawar Pakistan. Material Methods: A descriptive cross-sectional study convenient consecutive sampling technique at Department Medicine Khyber Teaching Hospital Peshawar. total 179 patients were recruited curren...

UNLABELLED Dengue virus is a major human pathogen responsible for 400 million infections yearly. As with other RNA viruses, daunting challenges to antiviral design exist due to the high error rates of RNA-dependent RNA synthesis. Indeed, treatment of dengue virus infection with a nucleoside analog resulted in the expected genetic selection of resistant viruses in tissue culture and in mice. How...

chemotherapy research highly prioritizes overcoming the multidrug resistance (mdr) in human tumors. liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. liposomes were prepared using different active loading techniques. the influence of diff...

We investigated the emergence and evolution of drug-resistant tuberculosis (TB) in an HIV co-infected population at a South African gold mine with a well-functioning TB control program. Of 128 patients with drug-resistant TB diagnosed during January 2003-November 2005, a total of 77 had multidrug-resistant (MDR) TB, 26 had pre-extensively drug-resistant TB (XDR TB), and 5 had XDR TB. Genotyping...

Non-tuberculous Mycobacteria (NTM) are emerging as an important opportunistic pathogen. Since clinical presentation of NTM infection is similar to tuberculosis (TB), patients present suspected TB or drug resistant TB. Presently in the National Tuberculosis Elimination Programme (NTEP ) not being speciated, but there urgent need characterize so that appropriate treatment can be given many specie...

Antituberculosis drug resistance is increasing both in theUnitedKingdomand internationally. 2 It has come to greater public attention with the emergence of extensively drug resistant tuberculosis (box 1) in South Africa, where an outbreak proved rapidly fatal among peoplewith advancedHIV infection. In this articlewe review recent global and UK trends in drug resistant tuberculosis and summarise...

Tuberculosis has re-emerged as a serious public health threat worldwide because of a significant increase in multiple drug resistant Mycobacterium tuberculosis varieties and a synergy between HIV and M. tuberculosis infection. It has been over 40 years since a new drug for tuberculosis has been discovered. The increasing emergence of drug resistant TB, and HIV infection, which compromises host ...