this paper presents a novel formulation and numerical solutions for adhesively bonded composite joints with non-linear (softening) adhesive behaviour. the presented approach has the capability of choosing arbitrary loadings and boundary conditions. in this model adherends are orthotropic laminates that obey classical lamination theory. the stacking sequences can be either symmetric or asymmetri...

The drug content in adhesive mixtures for inhalation is known to influence their dispersion performance, but the direction and magnitude of this influence depends on other variables. In the past decades several mechanisms have been postulated to explain this finding and a number of possible interacting variables have been identified. Still, the role of drug content in the formulation of adhesiv...

mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. several synthetic polymers are in use for this purpose. since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controlled del...

The efficacy of nucleus-targeted drug- or gene-carrying nanoparticles may be limited by slow transport through the molecularly crowded cytoplasm following endosome escape. Cytoskeletal elements and cellular organelles may pose steric and/or adhesive obstacles to the efficient intracellular transport of nanoparticles. To potentially reduce adhesive interactions of colloids with intracellular com...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

background: the purpose of this study was to evaluate the influence of three different luting protocols on shear bond strength of computer aided design/computer aided manufacturing (cad/cam) resin nanoceramic (rnc) material to dentin. materials and methods: in this in vitro study, 30 disks were milled from rnc blocks (lava ultimate/3m espe) with cad/cam technology. the disks were subsequently c...

background: esthetic demands among patients have led to the introduction of tooth-colored restorations. composite resins bond to enamel applying acid etch technique. total etch adhesion systems are still considered as golden standard among bonding systems. however, clinicians have tendency towards using adhesive systems with a simplified application procedure. the aim of the present study is to...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

Mechanotargeting of Atherogenic Endothelium In article number 202300137, Pouria Fattahi, Sulin Zhang, Peter J. Butler, and colleagues provide direct evidence for cell mechanics-based targeting nanoparticles (NPs) to atherogenic endothelium, a drug-delivery strategy termed, mechanotargeting. Microcontact-patterned adhesive islands induce endothelial cells adopt prescribed morphologies that mimic...

PURPOSE To investigate the effectiveness of fibrin glue (laparoscopic via) into promote the hemostasis of a spleen injury on a heparinized porcine model. METHODS Eighteen Landrace porcine were submitted to laparoscopic spleen injury and randomly distributed: GHA (heparin plus adhesive), GH (heparin without adhesive) and GS (Sham - without heparin or adhesive). Ten minutes before the surgical ...