Growth and carcass traits of St. Croix White (STX; n = 22) and Dorper X St. Croix White (DRP; n = 18) lambs fed a concentrate ration were evaluated. Starting two weeks after weaning (63 d of age) lambs were fed a commercial diet at 4 percent BW•hd-1•d-1. Lambs were slaughtered at a BW of 30 kg. Carcass weight, fat thickness over the 12th rib, rib eye area (REA), percent KPH and leg circumferenc...

Metabolic energy preferentially produced by glycolysis was an advantageous metabolic phenotype of cancer cells. It is also an essential contributor to the progression of multidrug resistance in cancer cells. By developing human breast cancer MCF-7 cells resistant to doxorubicin (DOX) (MCF-7/MDR cells), the effects and mechanisms of 2-deoxy-D-glucose (2DG), a glucose analogue, on reversing multi...

Glucose injections attenuate deficits in memory under several conditions in both rodents and humans. The present study examined effects of glucose on memory in two such amnesic populations, scopolamine-treated and old mice, and then assessed effects of glucose on brain (lHJ2deoxyglucose (2DG) uptake. In Experiment lA, scopolamine (3 mg/kg, i.p.) significantly impaired performance of mice tested...

OBJECTIVE To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. METHODS The LD50 of 2DG (in water) was determined in rats and mice by p.o. route and in mice by i.v. route. The effect of 2-DG (250 mg/kg, 500 mg/kg, and 1000 mg/kg, i.v.) was studied on various ...

Abstract Circulating nonadherent monocytes can migrate to extravascular sites by a process that involves adherence. Alterations in intracellular metabolism shape the immunological phenotype of phagocytes upon activation. To determine effect adherence on their metabolic and functional response human were stimulated with LPS under adherent conditions. Adherent (relative monocytes) produced less T...

We describe a new family of weak p-th order accurate SDE time integration schemes, called the Direct Richardson p-th order accurate (DRp) schemes. The DRp schemes use the idea of Richardson extrapolation on Euler time steps, performed by way of an acceptance-rejection algorithm. Previous applications of Richardson extrapolation to the Euler scheme are applicable only when the objective is to es...

In this study we describe the identification and structure-function analysis of a novel death-associated protein (DAP) kinase-related protein, DRP-1. DRP-1 is a 42-kDa Ca(2+)/calmodulin (CaM)-regulated serine threonine kinase which shows high degree of homology to DAP kinase. The region of homology spans the catalytic domain and the CaM-regulatory region, whereas the remaining C-terminal part o...

The glamor in the IT domain is in the project. Major projects command the attention of the profession; methods for managing, controling and planning projects have been developed and refined; metrics, testing and validation routines, and quality assurance processes are fundamental. On the other hand, much of the day-to-day routine of the IT function is concerned with continuing, rather than proj...

Apoptosis of type II alveolar epithelial cells (AECs-II) is a key determinant of initiation and progression of lung fibrosis. However, the mechanism of miR-30a participation in the regulation of AECs-II apoptosis is ambiguous. In this study, we investigated whether miR-30a could block AECs-II apoptosis by repressing mitochondrial fission dependent on dynamin-related protein-1 (Drp-1). The level...