نتایج جستجو برای: drosha

تعداد نتایج: 598  

2012
Shinji Kawai Atsuo Amano

MicroRNAs (miRNAs) are noncoding RNAs that function as key posttranscriptional regulators of gene expression. miRNA maturation is controlled by the DROSHA microprocessor complex. However, the detailed mechanism of miRNA biogenesis remains unclear. We show that the tumor suppressor breast cancer 1 (BRCA1) accelerates the processing of miRNA primary transcripts. BRCA1 increased the expressions of...

Journal: :Cold Spring Harbor Symposia on Quantitative Biology 2006

Journal: :EMBO reports 2012
Taeko Wada Jiro Kikuchi Yusuke Furukawa

Relatively little is known about the regulatory mechanisms of the Drosha/DGCR8 complex, which processes miRNAs at the initial step of biogenesis. We found that histone deacetylase 1 (HDAC1) increases the expression levels of mature miRNAs despite repressing the transcription of host genes. HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the...

2012
Chenfeng He Ying-Xin Li Guangxin Zhang Zuguang Gu Rong Yang Jie Li Zhi John Lu Zhi-Hua Zhou Chenyu Zhang Jin Wang

BACKGROUND MicroRNAs are known to be generated from primary transcripts mainly through the sequential cleavages by two enzymes, Drosha and Dicer. The sequence of a mature microRNA, especially the 'seeding sequence', largely determines its binding ability and specificity to target mRNAs. Therefore, methods that predict mature microRNA sequences with high accuracy will benefit the identification ...

Journal: :Haematologica 2012
Carlos Santamaría Sandra Muntión Beatriz Rosón Belén Blanco Olga López-Villar Soraya Carrancio Fermín M Sánchez-Guijo María Díez-Campelo Stela Alvarez-Fernández María E Sarasquete Javier de las Rivas Marcos González Jesús F San Miguel María Consuelo Del Cañizo

UNLABELLED Background Recent findings suggest that a specific deletion of Dicer1 in mesenchymal stromal cell-derived osteoprogenitors triggers several features of myelodysplastic syndrome in a murine model. Our aim was to analyze DICER1 and DROSHA gene and protein expression in mesenchymal stromal cells (the osteoblastic progenitors) obtained from bone marrow of myelodysplastic syndrome patient...

2011
Youn-Jae Kim Se-Jeong Park Eun Young Choi Sol Kim Hee Jin Kwak Byong Chul Yoo Heon Yoo Seung-Hoon Lee Daesoo Kim Jong Bae Park Jong Heon Kim

Aberrant miR-21 expression is closely associated with cell proliferation, anti-apoptosis, migration, invasion, and metastasis in various cancers. However, the regulatory mechanism of miR-21 biogenesis is largely unknown. Here, we demonstrated that the tumor suppressor PTEN negatively regulates the expression of oncogenic miR-21 at the post-transcriptional level. Moreover, our results suggest th...

Journal: :Bioinformatics 2007
Snorre A. Helvik Ola R. Snøve Pål Sætrom

MOTIVATION Mature microRNAs (miRNAs) are processed from long hairpin transcripts. Even though it is only the first of several steps, the initial Drosha processing defines the mature product and is characteristic for all miRNA genes. Methods that can separate between true and false processing sites are therefore essential to miRNA gene discovery. RESULTS We present a classifier that predicts 5...

2017
Huiwu Ouyang Kai Zhang Kristi Fox-Walsh Yang Yang Chen Zhang Jie Huang Hairi Li Yu Zhou Xiang-Dong Fu

The Ewing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established roles in transcription, pre-mRNA processing and DNA damage response. By generating high quality EWS–RNA interactome, we uncovered its specific and prevalent interaction with a large subset of primary microRNAs (pri-miRNAs) in mammalian cells. Knockdown of EWS reduced, whereas overexpression enhanced, th...

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