The DREAM (Dp/Retinoblastoma(Rb)-like/E2F/MuvB) transcriptional repressor complex acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular quiescence. How DREAM's three functional components, the E2F-DP heterodimer, the Rb-like pocket protein, and the MuvB subcomplex, form and function at target gene promoters remains unknown. The current model invokes that the ...

Objective. Violent dream content and its acting out during rapid eye movement sleep are considered distinctive for rapid eye movement sleep behaviour disorder (RBD). This study reports first quantitative data on dreaming in a cohort of patients with treated Wilson's disease (WD) and in patients with WD with RBD. Methods. Retrospective questionnaires on different dimensions of dreaming and a pro...

Numerous neuroimaging studies have strongly implicated the amygdala in dreaming. Various neuropsychological dream theories propose roles for the amygdala in dreaming (particularly in the generation of dream affect), however little empirical research on its function in dreaming exists. Urbach Wiethe Disease is a very rare genetic condition which leads to calcification of the amygdala over time. ...

One of the major components required for the construction of future complex real-time computer systems (RTCS's) needed in safety-critical applications is a timeliness-guaranteed operating system. A model of an operating system kernel called the DREAM kernel that can support both conventional real-time processes and new-style real-time objects has been formulated recently. The key emphasis in fo...

From Kant comes the statement: " The crazy person is a dreamer in the waking state. " Schopenhauer formulated the same thought thus: The dream is a short insanity, insanity is a long dream. The mad and the dreamer are indeed neighbors in the land of otherworldliness. Both have the courage to risk the trip beyond the boundaries of natural reality. The dreamer returns from this daring trip someti...

This paper addresses claims that dreams can be a source of personal insight. Whereas there has been anecdotal backing for such claims, there is now tangential support from findings of the facilitative effect of sleep on cognitive insight, and of REM sleep in particular on emotional memory consolidation. Furthermore, the presence in dreams of metaphorical representations of waking life indicates...

PURPOSE To evaluate morning dream recall frequency and content in patients with temporal lobe epilepsy (TLE). METHODS Fifty-two patients with pharmacoresistant TLE submitted to a written dream diary during five consecutive days and continuous video-electroencephalographic (video-EEG) monitoring. A matched control group of 41 healthy subjects completed the same diary at home. The number of rec...

The Resource Description Framework (RDF) and SPARQL query language are gaining wide popularity and acceptance. In this paper, we present DREAM, a distributed and adaptive RDF system. As opposed to existing RDF systems, DREAM avoids partitioning RDF datasets and partitions only SPARQL queries. By not partitioning datasets, DREAM offers a general paradigm for different types of pattern matching q...

The intrinsic mechanisms that promote the degeneration of retinal ganglion cells (RGCs) following the activation of N-Methyl-D-aspartic acid-type glutamate receptors (NMDARs) are unclear. In this study, we have investigated the role of downstream regulatory element antagonist modulator (DREAM) in NMDA-mediated degeneration of the retina. NMDA, phosphate-buffered saline (PBS), and MK801 were inj...